GSTA5 (glutathione S-transferase alpha 5)

2014-11-01  

Identity

HGNC
LOCATION
6p12.2
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 221357
MIM: 607605
HGNC: 19662
Ensembl: ENSG00000182793

Variants:

dbSNP: 221357
ClinVar: 221357
TCGA: ENSG00000182793
COSMIC: GSTA5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182793ENST00000284562Q7RTV2
ENSG00000182793ENST00000370989Q7RTV2

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
196646892010The human hGSTA5 gene encodes an enzymatically active protein.2

Citation

Dessen P

GSTA5 (glutathione S-transferase alpha 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64076/gsta5