GSTM3 (glutathione S-transferase mu 3)

2003-06-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
GST5,GSTB,GSTM3-3,GTM3
FUSION GENES

Other Information

Locus ID:

NCBI: 2947
MIM: 138390
HGNC: 4635
Ensembl: ENSG00000134202

Variants:

dbSNP: 2947
ClinVar: 2947
TCGA: ENSG00000134202
COSMIC: GSTM3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134202ENST00000256594P21266
ENSG00000134202ENST00000256594Q6FGJ9
ENSG00000134202ENST00000361066P21266
ENSG00000134202ENST00000361066Q6FGJ9
ENSG00000134202ENST00000540225A0A0A0MTN3

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443340AnemiaDiseaseVariantAnnotationassociatedPKPD19786980
PA443937Drug ToxicityDiseaseClinicalAnnotation, VariantAnnotationambiguousPD19786980, 22188361
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationambiguousPKPD19786980, 22188361
PA445301Peripheral Nervous System DiseasesDiseaseVariantAnnotationassociatedPKPD19786980
PA445846ThrombocytopeniaDiseaseVariantAnnotationassociatedPKPD19786980
PA449014cisplatinChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD19786980, 22188361
PA449165cyclophosphamideChemicalClinicalAnnotation, VariantAnnotationambiguousPKPD19786980, 22188361
PA450688olanzapineChemicalClinicalAnnotation, VariantAnnotationassociatedPK23559402

References

Pubmed IDYearTitleCitations
161123012005NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.174
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
160069972005A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.52
189907502008Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk.44
165097652006Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies.43
197869802010Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients.43
182586092008A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.41
167651452006Pharmacokinetics and toxicity of docetaxel: role of CYP3A, MDR1, and GST polymorphisms.33
180657252008Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.32

Citation

Dessen P

GSTM3 (glutathione S-transferase mu 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40770/gstm3