GSTO1 (glutathione S-transferase omega 1)

2008-08-01  

Identity

HGNC
LOCATION
10q25.1
LOCUSID
ALIAS
GSTO
FUSION GENES

Other Information

Locus ID:

NCBI: 9446
MIM: 605482
HGNC: 13312
Ensembl: ENSG00000148834

Variants:

dbSNP: 9446
ClinVar: 9446
TCGA: ENSG00000148834
COSMIC: GSTO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148834ENST00000369710P78417
ENSG00000148834ENST00000369713P78417
ENSG00000148834ENST00000369713V9HWG9
ENSG00000148834ENST00000432659Q5TA01
ENSG00000148834ENST00000445155Q5TA02
ENSG00000148834ENST00000539281P78417

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin C (ascorbate) metabolismREACTOMER-HSA-196836
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
348264182022Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.2
349591922022Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.0
360515332022The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.0
361291432022GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.3
348264182022Association of GSTO1, GSTO2, GSTP1, GPX1 and SOD2 polymorphism with primary open angle glaucoma.2
349591922022Proposed mechanism for monomethylarsonate reductase activity of human omega-class glutathione transferase GSTO1-1.0
360515332022The Role of CD40, CD86, and Glutathione S-Transferase Omega 1 in the Pathogenesis of Chronic Obstructive Pulmonary Disease.0
361291432022GSTO1 confers drug resistance in HCT‑116 colon cancer cells through an interaction with TNFαIP3/A20.3
332361612021Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.4
334705512021Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.0
335837322021Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.6
347793802021Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.0
332361612021Glutathione S‑transferase ω 1 promotes the proliferation, migration and invasion, and inhibits the apoptosis of non‑small cell lung cancer cells, via the JAK/STAT3 signaling pathway.4
334705512021Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.0
335837322021Airways glutathione S-transferase omega-1 and its A140D polymorphism are associated with severity of inflammation and respiratory dysfunction in cystic fibrosis.6

Citation

Dessen P

GSTO1 (glutathione S-transferase omega 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50314/gsto1