Identity
HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
GSTZ1-1,MAAI,MAAID,MAI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2954
MIM: 603758
HGNC: 4643
Ensembl: ENSG00000100577
Variants:
dbSNP: 2954
ClinVar: 2954
TCGA: ENSG00000100577
COSMIC: GSTZ1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA165947835 | dichloroacetic acid | Chemical | MultilinkAnnotation | associated | 27143230 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36905252 | 2023 | Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells. | 1 |
| 37742772 | 2023 | Clinical physiology and pharmacology of GSTZ1/MAAI. | 1 |
| 36905252 | 2023 | Glutathione S-transferase zeta 1 alters the HMGB1/GPX4 axis to drive ferroptosis in bladder cancer cells. | 1 |
| 37742772 | 2023 | Clinical physiology and pharmacology of GSTZ1/MAAI. | 1 |
| 33931597 | 2021 | GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. | 109 |
| 33931597 | 2021 | GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. | 109 |
| 31782257 | 2020 | GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells. | 5 |
| 32357971 | 2020 | Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes. | 3 |
| 31782257 | 2020 | GSTZ1-1 downregulates Wnt/β-catenin signalling in hepatocellular carcinoma cells. | 5 |
| 32357971 | 2020 | Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes. | 3 |
| 31267557 | 2019 | GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. | 24 |
| 31624634 | 2019 | GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. | 10 |
| 31666108 | 2019 | GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. | 28 |
| 31267557 | 2019 | GSTZ1-1 Deficiency Activates NRF2/IGF1R Axis in HCC via Accumulation of Oncometabolite Succinylacetone. | 24 |
| 31624634 | 2019 | GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial. | 10 |
Citation
Dessen P
GSTZ1 (glutathione S-transferase zeta 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-06-01
Online version: http://atlasgeneticsoncology.org/gene/40776/gstz1
