Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GTF2A1 (general transcription factor IIA subunit 1)

Identity

Alias_namesglucose regulated protein, 58kD pseudogene
general transcription factor IIA, 1, 19/37kDa
general transcription factor IIA 1
Alias_symbol (synonym)TFIIA
Other aliasTF2A1
TFIIA-42
TFIIAL
HGNC (Hugo) GTF2A1
LocusID (NCBI) 2957
Atlas_Id 51238
Location 14q31.1  [Link to chromosome band 14q31]
Location_base_pair Starts at 81175453 and ends at 81221231 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CEP128 (14q31.1) / GTF2A1 (14q31.1)GTF2A1 (14q31.1) / KIAA0391 (14q13.2)PLCB1 (20p12.3) / GTF2A1 (14q31.1)
GTF2A1 14q31.1 / KIAA0391 14q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(14;14)(q13;q31) GTF2A1/KIAA0391
t(14;14)(q24;q31) GTF2A1/POMT2

External links

Nomenclature
HGNC (Hugo)GTF2A1   4646
Cards
Entrez_Gene (NCBI)GTF2A1  2957  general transcription factor IIA subunit 1
AliasesTF2A1; TFIIA; TFIIA-42; TFIIAL
GeneCards (Weizmann)GTF2A1
Ensembl hg19 (Hinxton)ENSG00000165417 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000165417 [Gene_View]  ENSG00000165417 [Sequence]  chr14:81175453-81221231 [Contig_View]  GTF2A1 [Vega]
ICGC DataPortalENSG00000165417
TCGA cBioPortalGTF2A1
AceView (NCBI)GTF2A1
Genatlas (Paris)GTF2A1
WikiGenes2957
SOURCE (Princeton)GTF2A1
Genetics Home Reference (NIH)GTF2A1
Genomic and cartography
GoldenPath hg38 (UCSC)GTF2A1  -     chr14:81175453-81221231 -  14q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GTF2A1  -     14q31.1   [Description]    (hg19-Feb_2009)
GoldenPathGTF2A1 - 14q31.1 [CytoView hg19]  GTF2A1 - 14q31.1 [CytoView hg38]
ImmunoBaseENSG00000165417
Mapping of homologs : NCBIGTF2A1 [Mapview hg19]  GTF2A1 [Mapview hg38]
OMIM600520   
Gene and transcription
Genbank (Entrez)AK021641 AK025178 BC041410 BC050703 BC107155
RefSeq transcript (Entrez)NM_001278940 NM_015859 NM_201595
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GTF2A1
Cluster EST : UnigeneHs.592334 [ NCBI ]
CGAP (NCI)Hs.592334
Alternative Splicing GalleryENSG00000165417
Gene ExpressionGTF2A1 [ NCBI-GEO ]   GTF2A1 [ EBI - ARRAY_EXPRESS ]   GTF2A1 [ SEEK ]   GTF2A1 [ MEM ]
Gene Expression Viewer (FireBrowse)GTF2A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2957
GTEX Portal (Tissue expression)GTF2A1
Human Protein AtlasENSG00000165417-GTF2A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52655   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52655  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52655
Splice isoforms : SwissVarP52655
PhosPhoSitePlusP52655
Domains : Interpro (EBI)TFIIA_asu/bsu    TFIIA_b-brl   
Domain families : Pfam (Sanger)TFIIA (PF03153)   
Domain families : Pfam (NCBI)pfam03153   
Domain families : Smart (EMBL)TFIIA (SM01371)  
Conserved Domain (NCBI)GTF2A1
DMDM Disease mutations2957
Blocks (Seattle)GTF2A1
PDB (RSDB)1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
PDB Europe1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
PDB (PDBSum)1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
PDB (IMB)1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
Structural Biology KnowledgeBase1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
SCOP (Structural Classification of Proteins)1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
CATH (Classification of proteins structures)1NVP    5FUR    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD    5M4S   
SuperfamilyP52655
Human Protein Atlas [tissue]ENSG00000165417-GTF2A1 [tissue]
Peptide AtlasP52655
HPRD02748
IPIIPI00004350   IPI00401787   IPI00872252   IPI01026026   
Protein Interaction databases
DIP (DOE-UCLA)P52655
IntAct (EBI)P52655
FunCoupENSG00000165417
BioGRIDGTF2A1
STRING (EMBL)GTF2A1
ZODIACGTF2A1
Ontologies - Pathways
QuickGOP52655
Ontology : AmiGORNA polymerase II repressing transcription factor binding  DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIA complex  transcription factor TFIIA complex  cytosol  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription factor binding  RNA polymerase II general transcription initiation factor activity  TBP-class protein binding  snRNA transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIRNA polymerase II repressing transcription factor binding  DNA binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIA complex  transcription factor TFIIA complex  cytosol  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription factor binding  RNA polymerase II general transcription initiation factor activity  TBP-class protein binding  snRNA transcription by RNA polymerase II  protein heterodimerization activity  positive regulation of nucleic acid-templated transcription  
Pathways : KEGGBasal transcription factors    Viral carcinogenesis   
NDEx NetworkGTF2A1
Atlas of Cancer Signalling NetworkGTF2A1
Wikipedia pathwaysGTF2A1
Orthology - Evolution
OrthoDB2957
GeneTree (enSembl)ENSG00000165417
Phylogenetic Trees/Animal Genes : TreeFamGTF2A1
HOGENOMP52655
Homologs : HomoloGeneGTF2A1
Homology/Alignments : Family Browser (UCSC)GTF2A1
Gene fusions - Rearrangements
Fusion : MitelmanGTF2A1/KIAA0391 [14q31.1/14q13.2]  
Fusion PortalGTF2A1 14q31.1 KIAA0391 14q13.2 LUAD
Fusion : QuiverGTF2A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTF2A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTF2A1
dbVarGTF2A1
ClinVarGTF2A1
1000_GenomesGTF2A1 
Exome Variant ServerGTF2A1
ExAC (Exome Aggregation Consortium)ENSG00000165417
GNOMAD BrowserENSG00000165417
Varsome BrowserGTF2A1
Genetic variants : HAPMAP2957
Genomic Variants (DGV)GTF2A1 [DGVbeta]
DECIPHERGTF2A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGTF2A1 
Mutations
ICGC Data PortalGTF2A1 
TCGA Data PortalGTF2A1 
Broad Tumor PortalGTF2A1
OASIS PortalGTF2A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTF2A1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGTF2A1
Mutations and Diseases : HGMDGTF2A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GTF2A1
DgiDB (Drug Gene Interaction Database)GTF2A1
DoCM (Curated mutations)GTF2A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GTF2A1 (select a term)
intoGenGTF2A1
Cancer3DGTF2A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600520   
Orphanet
DisGeNETGTF2A1
MedgenGTF2A1
Genetic Testing Registry GTF2A1
NextProtP52655 [Medical]
TSGene2957
GENETestsGTF2A1
Target ValidationGTF2A1
Huge Navigator GTF2A1 [HugePedia]
snp3D : Map Gene to Disease2957
BioCentury BCIQGTF2A1
ClinGenGTF2A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2957
Chemical/Pharm GKB GenePA29033
Clinical trialGTF2A1
Miscellaneous
canSAR (ICR)GTF2A1 (select the gene name)
DataMed IndexGTF2A1
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGTF2A1
EVEXGTF2A1
GoPubMedGTF2A1
iHOPGTF2A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:45:54 CET 2019
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