| Nomenclature |
|---|
| HGNC (Hugo) | GTF2H3 4657 |
| Cards |
|---|
| Entrez_Gene (NCBI) | GTF2H3 2967 general transcription factor IIH subunit 3 |
| Aliases | BTF2; P34; TFB4; TFIIH |
| GeneCards (Weizmann) | GTF2H3 |
| Ensembl hg19 (Hinxton) | ENSG00000111358 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000111358 [Gene_View] ENSG00000111358 [Sequence] chr12:123633739-123662604 [Contig_View] GTF2H3 [Vega] |
| ICGC DataPortal | ENSG00000111358 |
| TCGA cBioPortal | GTF2H3 |
| AceView (NCBI) | GTF2H3 |
| Genatlas (Paris) | GTF2H3 |
| WikiGenes | 2967 |
| SOURCE (Princeton) | GTF2H3 |
| Genetics Home Reference (NIH) | GTF2H3 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | GTF2H3 - chr12:123633739-123662604 + 12q24.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | GTF2H3 - 12q24.31 [Description] (hg19-Feb_2009) |
| GoldenPath | GTF2H3 - 12q24.31 [CytoView hg19] GTF2H3 - 12q24.31 [CytoView hg38] |
| ImmunoBase | ENSG00000111358 |
| Mapping of homologs : NCBI | GTF2H3 [Mapview hg19] GTF2H3 [Mapview hg38] |
| OMIM | 601750 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK298128 AK313200 AL558542 AL600169 BC013216 |
| RefSeq transcript (Entrez) | NM_001271866 NM_001271867 NM_001271868 NM_001516 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | GTF2H3 |
| Cluster EST : Unigene | Hs.355348 [ NCBI ] |
| CGAP (NCI) | Hs.355348 |
| Alternative Splicing Gallery | ENSG00000111358 |
| Gene Expression | GTF2H3 [ NCBI-GEO ] GTF2H3 [ EBI - ARRAY_EXPRESS ]
GTF2H3 [ SEEK ] GTF2H3 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | GTF2H3 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 2967 |
| GTEX Portal (Tissue expression) | GTF2H3 |
| Human Protein Atlas | ENSG00000111358-GTF2H3 [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13889 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q13889 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13889 |
| Splice isoforms : SwissVar | Q13889 |
| PhosPhoSitePlus | Q13889 |
| Domains : Interpro (EBI) | TFIIH_Tfb4/GTF2H3 vWFA_dom_sf |
| Domain families : Pfam (Sanger) | Tfb4 (PF03850) |
| Domain families : Pfam (NCBI) | pfam03850 |
| Conserved Domain (NCBI) | GTF2H3 |
| DMDM Disease mutations | 2967 |
| Blocks (Seattle) | GTF2H3 |
| PDB (RSDB) | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| PDB Europe | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| PDB (PDBSum) | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| PDB (IMB) | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| Structural Biology KnowledgeBase | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| SCOP (Structural Classification of Proteins) | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| CATH (Classification of proteins structures) | 5IVW 5IY6 5IY7 5IY8 5IY9 5O85 5OF4 |
| Superfamily | Q13889 |
| Human Protein Atlas [tissue] | ENSG00000111358-GTF2H3 [tissue] |
| Peptide Atlas | Q13889 |
| HPRD | 07531 |
| IPI | IPI00100791 IPI01011043 IPI01013414 IPI01011371 IPI01010954 IPI01010418 IPI01009488 IPI01010821 IPI01015537 IPI01009911 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13889 |
| IntAct (EBI) | Q13889 |
| FunCoup | ENSG00000111358 |
| BioGRID | GTF2H3 |
| STRING (EMBL) | GTF2H3 |
| ZODIAC | GTF2H3 |
| Ontologies - Pathways |
|---|
| QuickGO | Q13889 |
| Ontology : AmiGO | core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex nucleotide-excision repair, DNA duplex unwinding protein kinase activity protein binding nucleus nucleoplasm nucleoplasm transcription factor TFIID complex transcription factor TFIIH holo complex transcription factor TFIIH holo complex DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping DNA-dependent ATPase activity DNA-dependent ATPase activity RNA polymerase II CTD heptapeptide repeat kinase activity RNA polymerase II CTD heptapeptide repeat kinase activity RNA polymerase II general transcription initiation factor activity nucleotide-excision repair, DNA incision metal ion binding protein N-terminus binding phosphorylation of RNA polymerase II C-terminal domain global genome nucleotide-excision repair transcriptional preinitiation complex |
| Ontology : EGO-EBI | core TFIIH complex portion of holo TFIIH complex transcription factor TFIIH core complex nucleotide-excision repair, DNA duplex unwinding protein kinase activity protein binding nucleus nucleoplasm nucleoplasm transcription factor TFIID complex transcription factor TFIIH holo complex transcription factor TFIIH holo complex DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription by RNA polymerase II transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping DNA-dependent ATPase activity DNA-dependent ATPase activity RNA polymerase II CTD heptapeptide repeat kinase activity RNA polymerase II CTD heptapeptide repeat kinase activity RNA polymerase II general transcription initiation factor activity nucleotide-excision repair, DNA incision metal ion binding protein N-terminus binding phosphorylation of RNA polymerase II C-terminal domain global genome nucleotide-excision repair transcriptional preinitiation complex |
| Pathways : KEGG | Basal transcription factors Nucleotide excision repair Viral carcinogenesis |
| NDEx Network | GTF2H3 |
| Atlas of Cancer Signalling Network | GTF2H3 |
| Wikipedia pathways | GTF2H3 |
| Orthology - Evolution |
|---|
| OrthoDB | 2967 |
| GeneTree (enSembl) | ENSG00000111358 |
| Phylogenetic Trees/Animal Genes : TreeFam | GTF2H3 |
| HOGENOM | Q13889 |
| Homologs : HomoloGene | GTF2H3 |
| Homology/Alignments : Family Browser (UCSC) | GTF2H3 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | GTF2H3/DDX55 [12q24.31/12q24.31] |
| Fusion : Mitelman | GTF2H3/PGC [12q24.31/6p21.1] [t(6;12)(p21;q24)] |
| Fusion Portal | GTF2H3 12q24.31 PGC 6p21.1 GBM |
| Fusion : Quiver | GTF2H3 |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | GTF2H3 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | GTF2H3 |
| dbVar | GTF2H3 |
| ClinVar | GTF2H3 |
| 1000_Genomes | GTF2H3 |
| Exome Variant Server | GTF2H3 |
| ExAC (Exome Aggregation Consortium) | ENSG00000111358 |
| GNOMAD Browser | ENSG00000111358 |
| Varsome Browser | GTF2H3 |
| Genetic variants : HAPMAP | 2967 |
| Genomic Variants (DGV) | GTF2H3 [DGVbeta] |
| DECIPHER | GTF2H3 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | GTF2H3 |
| Mutations |
|---|
| ICGC Data Portal | GTF2H3 |
| TCGA Data Portal | GTF2H3 |
| Broad Tumor Portal | GTF2H3 |
| OASIS Portal | GTF2H3 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | GTF2H3 [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | GTF2H3 |
| Mutations and Diseases : HGMD | GTF2H3 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search GTF2H3 |
| DgiDB (Drug Gene Interaction Database) | GTF2H3 |
| DoCM (Curated mutations) | GTF2H3 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | GTF2H3 (select a term) |
| intoGen | GTF2H3 |
| Cancer3D | GTF2H3(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601750 |
| Orphanet | |
| DisGeNET | GTF2H3 |
| Medgen | GTF2H3 |
| Genetic Testing Registry | GTF2H3
|
| NextProt | Q13889 [Medical] |
| TSGene | 2967 |
| GENETests | GTF2H3 |
| Target Validation | GTF2H3 |
| Huge Navigator |
GTF2H3 [HugePedia] |
| snp3D : Map Gene to Disease | 2967 |
| BioCentury BCIQ | GTF2H3 |
| ClinGen | GTF2H3 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 2967 |
| Chemical/Pharm GKB Gene | PA29043 |
| Clinical trial | GTF2H3 |
| Miscellaneous |
|---|
| canSAR (ICR) | GTF2H3 (select the gene name) |
| DataMed Index | GTF2H3 |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 62 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | GTF2H3 |
| EVEX | GTF2H3 |
| GoPubMed | GTF2H3 |
| iHOP | GTF2H3 |
