GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)

2018-02-01  

Identity

HGNC
GUCY1B1
LOCATION
4q32.1
LOCUSID
2983
ALIAS
GC-S-beta-1,GC-SB3,GUC1B3,GUCB3,GUCSB3,GUCY1B3

Other Information

Locus ID:

NCBI: 2983
MIM: 139397
HGNC: 4687
Ensembl: ENSG00000061918

Variants:

dbSNP: 2983
ClinVar: 2983
TCGA: ENSG00000061918
COSMIC: GUCY1B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061918ENST00000264424Q02153
ENSG00000061918ENST00000502959E9PCN2
ENSG00000061918ENST00000503520Q02153
ENSG00000061918ENST00000505154B7Z685
ENSG00000061918ENST00000505764Q02153
ENSG00000061918ENST00000507146D6RC99
ENSG00000061918ENST00000513437B7Z685
ENSG00000061918ENST00000652626A0A494C1B9

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Gap junctionKEGGko04540
Long-term depressionKEGGko04730
Purine metabolismKEGGhsa00230
Gap junctionKEGGhsa04540
Long-term depressionKEGGhsa04730
Vascular smooth muscle contractionKEGGhsa04270
Vascular smooth muscle contractionKEGGko04270
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cGMP signalingKEGGhsa_M00694
cGMP signalingKEGGM00694
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
201053012010Crystal structure of the signaling helix coiled-coil domain of the beta1 subunit of the soluble guanylyl cyclase.29
247333952014Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.21
290248962018Identification of a soluble guanylate cyclase in RBCs: preserved activity in patients with coronary artery disease.13
218581792011Fluorescence dequenching makes haem-free soluble guanylate cyclase detectable in living cells.9
226906862012The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.9
222234822012Quaternary structure controls ligand dynamics in soluble guanylate cyclase.6
200246062010Evidence for cross-talk between atrial natriuretic peptide and nitric oxide receptors.4
200631082010Efficient expression of human soluble guanylate cyclase in Escherichia coli and its signaling-related interaction with nitric oxide.4
231793182013Subsequent gene expression pattern in dendritic cells following multiple trauma.3
268765362016The molecular mechanism of heme loss from oxidized soluble guanylate cyclase induced by conformational change.1

Citation

Dessen P

GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57286/gucy1b1