GYPA (glycophorin A (MNS blood group))

2011-04-01  

Identity

HGNC
LOCATION
4q31.21
LOCUSID
ALIAS
CD235a,GPA,GPErik,GPSAT,HGpMiV,HGpMiXI,HGpSta(C),MN,MNS,PAS-2

Other Information

Locus ID:

NCBI: 2993
MIM: 617922
HGNC: 4702
Ensembl: ENSG00000170180

Variants:

dbSNP: 2993
ClinVar: 2993
TCGA: ENSG00000170180
COSMIC: GYPA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170180ENST00000324022P02724
ENSG00000170180ENST00000360771A0A0C4DFT7
ENSG00000170180ENST00000503627E9PH25
ENSG00000170180ENST00000504786E7EQF3
ENSG00000170180ENST00000508337D6RJD8
ENSG00000170180ENST00000512064E9PD10
ENSG00000170180ENST00000512789Q13030
ENSG00000170180ENST00000535709A0A087WU29
ENSG00000170180ENST00000616983A0A087WU29
ENSG00000170180ENST00000641688A0A0C4DFT7
ENSG00000170180ENST00000642295A0A2R8Y7F9
ENSG00000170180ENST00000642713P02724
ENSG00000170180ENST00000642738K9JI14
ENSG00000170180ENST00000643148K9JIK7
ENSG00000170180ENST00000646447P02724

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640
MalariaKEGGko05144
MalariaKEGGhsa05144
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
211192052010Chromosome 4q31 locus in COPD is also associated with lung cancer.41
285226902017Resistance to malaria through structural variation of red blood cell invasion receptors.41
118618812002Natural selection on the erythrocyte surface.40
206031022010The membrane environment modulates self-association of the human GpA TM domain--implications for membrane protein folding and transmembrane signaling.31
257785312015Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells.29
240436272013Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design.23
252050962014Critical glycosylated residues in exon three of erythrocyte glycophorin A engage Plasmodium falciparum EBA-175 and define receptor specificity.15
199070192010The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes.14
262390592015Growing thrombi release increased levels of CD235a(+) microparticles and decreased levels of activated platelet-derived microparticles. Validation in ST-elevation myocardial infarction patients.12
282262422017<i>Plasmodium falciparum</i> ligand binding to erythrocytes induce alterations in deformability essential for invasion.12

Citation

Dessen P

GYPA (glycophorin A (MNS blood group))

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52159/gypa