GYPB (glycophorin B (MNS blood group))

2018-02-01 Affiliation

Identity

HGNC

GYPB

LOCATION

4q31.21

LOCUSID

2994

ALIAS

CD235b,GPB,GYP,GYPA,MNS,PAS-3,SS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2994
MIM: 617923
HGNC: 4703
Ensembl: ENSG00000250361

Variants:

dbSNP: 2994
ClinVar: 2994
TCGA: ENSG00000250361
COSMIC: GYPB

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000250361	ENST00000429670	E7ERJ5
ENSG00000250361	ENST00000502664	P06028
ENSG00000250361	ENST00000504951	D6RA87
ENSG00000250361	ENST00000505583	D6RA87
ENSG00000250361	ENST00000506516	D6RBP2
ENSG00000250361	ENST00000506679	D6RAD9
ENSG00000250361	ENST00000511198	D6RA87
ENSG00000250361	ENST00000513128	P06028
ENSG00000250361	ENST00000638448	A0A1W2PQZ9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Malaria	KEGG	ko05144
Malaria	KEGG	hsa05144
Hemostasis	REACTOME	R-HSA-109582
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

References

Pubmed ID	Year	Title	Citations
19279206	2009	Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1.	65
28522690	2017	Resistance to malaria through structural variation of red blood cell invasion receptors.	41
14638759	2003	Plasmodium falciparum is able to invade erythrocytes through a trypsin-resistant pathway independent of glycophorin B.	18
21283638	2011	Population genetics of GYPB and association study between GYPB*S/s polymorphism and susceptibility to P. falciparum infection in the Brazilian Amazon.	16
20431033	2010	Single PCR multiplex SNaPshot reaction for detection of eleven blood group nucleotide polymorphisms: optimization, validation, and one year of routine clinical use.	12
18067501	2008	Blood group genotyping for Jk(a)/Jk(b), Fy(a)/Fy(b), S/s, K/k, Kp(a)/Kp(b), Js(a)/Js(b), Co(a)/Co(b), and Lu(a)/Lu(b) with microarray beads.	10
14641872	2003	Mutations in GYPB exon 5 drive the S-s-U+(var) phenotype in persons of African descent: implications for transfusion.	8
28760933	2017	Genetic Evidence for Erythrocyte Receptor Glycophorin B Expression Levels Defining a Dominant Plasmodium falciparum Invasion Pathway into Human Erythrocytes.	7
17561857	2007	Detection of MNS hybrid molecules in the Thai population using PCR-SSP technique.	5
18510579	2008	Introduction of a real-time-based blood-group genotyping approach.	5

Citation

Dessen P

GYPB (glycophorin B (MNS blood group))

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57353/gypb