GZMK (granzyme K)

2014-11-01  

Identity

HGNC
GZMK
LOCATION
5q11.2
LOCUSID
3003
ALIAS
TRYP2

Other Information

Locus ID:

NCBI: 3003
MIM: 600784
HGNC: 4711
Ensembl: ENSG00000113088

Variants:

dbSNP: 3003
ClinVar: 3003
TCGA: ENSG00000113088
COSMIC: GZMK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113088ENST00000231009P49863

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
216660612011Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis.49
190599122009Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A.21
123844992002The 2.2-A crystal structure of human pro-granzyme K reveals a rigid zymogen with unusual features.20
173083072007Granzyme K directly processes bid to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death.19
247114072014Granzyme K synergistically potentiates LPS-induced cytokine responses in human monocytes.19
170089162007Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells.17
123877262003Formation of active monomers from tetrameric human beta-tryptase.11
174384532007Altered levels and molecular forms of granzyme k in plasma from septic patients.11
192018682009Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis.11
269366342016Extracellular granzyme K mediates endothelial activation through the cleavage of protease-activated receptor-1.7

Citation

Dessen P

GZMK (granzyme K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64142/gzmk