GZMM (granzyme M)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
LMET1,MET1
FUSION GENES

Other Information

Locus ID:

NCBI: 3004
MIM: 600311
HGNC: 4712
Ensembl: ENSG00000197540

Variants:

dbSNP: 3004
ClinVar: 3004
TCGA: ENSG00000197540
COSMIC: GZMM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197540ENST00000264553P51124
ENSG00000197540ENST00000592501U3KQV5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Complement cascadeREACTOMER-HSA-166658
Initial triggering of complementREACTOMER-HSA-166663
Alternative complement activationREACTOMER-HSA-173736

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
154943982004Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B.23
150287222004Granzyme M mediates a novel form of perforin-dependent cell death.21
271337192016Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling.20
185232842008NK cell protease granzyme M targets alpha-tubulin and disorganizes the microtubule network.19
125060192003The serine protease granzyme M is preferentially expressed in NK-cell, gamma delta T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity.18
204068242010Cleavage of survivin by Granzyme M triggers degradation of the survivin-X-linked inhibitor of apoptosis protein (XIAP) complex to free caspase activity leading to cytolysis of target tumor cells.14
218579422011Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.14
168187752006Granzyme M directly cleaves inhibitor of caspase-activated DNase (CAD) to unleash CAD leading to DNA fragmentation.12
210598952010Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71.12
191035892009Nucleophosmin is cleaved and inactivated by the cytotoxic granule protease granzyme M during natural killer cell-mediated killing.10

Citation

Dessen P

GZMM (granzyme M)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43668/gzmm