H1-0 (H1.0 linker histone)

2019-08-01  

Identity

HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
H1.0,H10,H1F0,H1FV

Other Information

Locus ID:

NCBI: 3005
MIM: 142708
HGNC: 4714
Ensembl: ENSG00000189060

Variants:

dbSNP: 3005
ClinVar: 3005
TCGA: ENSG00000189060
COSMIC: H1-0

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000189060ENST00000340857P07305

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
277080742016The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity.34
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
223346652012N- and C-terminal domains determine differential nucleosomal binding geometry and affinity of linker histone isotypes H1(0) and H1c.18
120800502002The requirement of H1 histones for a heterodimeric nuclear import receptor.15
121494192002H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors.14
299826882018Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage.9
275286172016Regulation of Cellular Dynamics and Chromosomal Binding Site Preference of Linker Histones H1.0 and H1.X.5
304308262018Binding Affinity and Function of the Extremely Disordered Protein Complex Containing Human Linker Histone H1.0 and Its Chaperone ProTα.4

Citation

Dessen P

H1-0 (H1.0 linker histone)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58100/h1-0