H1-2 (H1.2 linker histone, cluster member)

2014-05-01  

Identity

HGNC
H1-2
LOCATION
6p22.2
LOCUSID
3006
ALIAS
H1.2,H1C,H1F2,H1s-1,HIST1H1C

Other Information

Locus ID:

NCBI: 3006
MIM: 142710
HGNC: 4716
Ensembl: ENSG00000187837

Variants:

dbSNP: 3006
ClinVar: 3006
TCGA: ENSG00000187837
COSMIC: H1-2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187837ENST00000343677P16403

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.58
182585962008Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.49
155957312004Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.46
244769182014Mapping of six somatic linker histone H1 variants in human breast cancer cells uncovers specific features of H1.2.38
243609652013Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation.23
185684482008Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease.22
168544302006Linker histone H1 binds to disease associated amyloid-like fibrils.20
222492592012Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription.16
273901282016Hormone-induced repression of genes requires BRG1-mediated H1.2 deposition at target promoters.15
178799442008Histone H1.2 is translocated to mitochondria and associates with Bak in bleomycin-induced apoptotic cells.13

Citation

Dessen P

H1-2 (H1.2 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53900/h1-2