H1-3 (H1.3 linker histone, cluster member)

2014-05-01  

Identity

HGNC
H1-3
LOCATION
6p22.2
LOCUSID
3007
ALIAS
H1.3,H1D,H1F3,H1s-2,HIST1H1D

Other Information

Locus ID:

NCBI: 3007
MIM: 142210
HGNC: 4717
Ensembl: ENSG00000124575

Variants:

dbSNP: 3007
ClinVar: 3007
TCGA: ENSG00000124575
COSMIC: H1-3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124575ENST00000244534P16402

Pathways

PathwaySourceExternal ID
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
Formation of Senescence-Associated Heterochromatin Foci (SAHF)REACTOMER-HSA-2559584

References

Pubmed IDYearTitleCitations
244350472014Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma.58
192660772009Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966.48
155957312004Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry.46
198935842010Identification of 15 loci influencing height in a Korean population.41
255848612015Proteomic characterization of the nucleolar linker histone H1 interaction network.14
206857202010Differential expression profiling analyses identifies downregulation of 1p, 6q, and 14q genes and overexpression of 6p histone cluster 1 genes as markers of recurrence in meningiomas.12
262096082016Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence.8
208462172010Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.7
245257342014The C-terminal domain (CTD) in linker histones antagonizes anti-apoptotic proteins to modulate apoptotic outcomes at the mitochondrion.3

Citation

Dessen P

H1-3 (H1.3 linker histone, cluster member)

Atlas Genet Cytogenet Oncol Haematol. 2014-05-01

Online version: http://atlasgeneticsoncology.org/gene/53901/h1-3