H3-4 (H3.4 histone)

2019-08-01  

Identity

HGNC
H3-4
LOCATION
1q42.13
LOCUSID
8290
ALIAS
H3.4,H3/g,H3FT,H3t,HIST3H3

Other Information

Locus ID:

NCBI: 8290
MIM: 602820
HGNC: 4778
Ensembl: ENSG00000168148

Variants:

dbSNP: 8290
ClinVar: 8290
TCGA: ENSG00000168148
COSMIC: H3-4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168148ENST00000366696Q16695

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
Chromosome MaintenanceREACTOMER-HSA-73886
Telomere MaintenanceREACTOMER-HSA-157579
Packaging Of Telomere EndsREACTOMER-HSA-171306
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
Meiotic synapsisREACTOMER-HSA-1221632
DNA RepairREACTOMER-HSA-73894
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
234528512013H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.141
220993082011NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.134
180483442007JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.127
235392692013Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.98
229227422012Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α.85
228539512012Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor α target gene activation.74
246561322014A role for H3K4 monomethylation in gene repression and partitioning of chromatin readers.72
239082412013A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection.71
204980942010Structural basis of instability of the nucleosome containing a testis-specific histone variant, human H3T.70
184183852008Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.52

Citation

Dessen P

H3-4 (H3.4 histone)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58148/h3-4