H3C14 (H3 clustered histone 14)

2009-03-01  

Identity

HGNC
LOCATION
1q21.2
LOCUSID
ALIAS
H3,H3.2,H3/M,H3C13,H3C15,H3F2,H3FM,H3FN,HIST2H3C

Other Information

Locus ID:

NCBI: 126961
MIM: 142780
HGNC: 20503
Ensembl: ENSG00000203811

Variants:

dbSNP: 126961
ClinVar: 126961
TCGA: ENSG00000203811
COSMIC: H3C14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000203811ENST00000369158Q71DI3

Pathways

PathwaySourceExternal ID
Systemic lupus erythematosusKEGGko05322
Systemic lupus erythematosusKEGGhsa05322
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-7 signalingREACTOMER-HSA-1266695
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3REACTOMER-HSA-5625886
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase I TranscriptionREACTOMER-HSA-73864
RNA Polymerase I Promoter ClearanceREACTOMER-HSA-73854
RNA Polymerase I Promoter OpeningREACTOMER-HSA-73728
RNA Polymerase I Chain ElongationREACTOMER-HSA-73777
Gene Silencing by RNAREACTOMER-HSA-211000
Transcriptional regulation by small RNAsREACTOMER-HSA-5578749
Epigenetic regulation of gene expressionREACTOMER-HSA-212165
PRC2 methylates histones and DNAREACTOMER-HSA-212300
Negative epigenetic regulation of rRNA expressionREACTOMER-HSA-5250941
SIRT1 negatively regulates rRNA ExpressionREACTOMER-HSA-427359
NoRC negatively regulates rRNA expressionREACTOMER-HSA-427413
DNA methylationREACTOMER-HSA-5334118
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
MeiosisREACTOMER-HSA-1500620
Meiotic recombinationREACTOMER-HSA-912446
Developmental BiologyREACTOMER-HSA-1266738
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
HDACs deacetylate histonesREACTOMER-HSA-3214815
HDMs demethylate histonesREACTOMER-HSA-3214842
PKMTs methylate histone lysinesREACTOMER-HSA-3214841
RMTs methylate histone argininesREACTOMER-HSA-3214858
Positive epigenetic regulation of rRNA expressionREACTOMER-HSA-5250913
B-WICH complex positively regulates rRNA expressionREACTOMER-HSA-5250924
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionREACTOMER-HSA-427389

References

Pubmed IDYearTitleCitations
163620572006Histone demethylation by a family of JmjC domain-containing proteins.641
153457772004Human PAD4 regulates histone arginine methylation levels via demethylimination.288
198187182009A method for genetically installing site-specific acetylation in recombinant histones defines the effects of H3 K56 acetylation.196
222314002012Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance.101
194118442009Histone H3-K56 acetylation is important for genomic stability in mammals.91
262376452015Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.51
193630252009Phosphorylation of histone H3 Thr-45 is linked to apoptosis.45
221959652011A specific function for the histone chaperone NASP to fine-tune a reservoir of soluble H3-H4 in the histone supply chain.45
190411502009Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer.40
221004502012UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail.37

Citation

Dessen P

H3C14 (H3 clustered histone 14)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50806/h3c14