HABP4 (hyaluronan binding protein 4)

2011-09-01  

Identity

HGNC
HABP4
LOCATION
9q22.32
LOCUSID
22927
ALIAS
IHABP-4,IHABP4,Ki-1/57,SERBP1L
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22927
MIM: 617369
HGNC: 17062
Ensembl: ENSG00000130956

Variants:

dbSNP: 22927
ClinVar: 22927
TCGA: ENSG00000130956
COSMIC: HABP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130956ENST00000375249Q5JVS0
ENSG00000130956ENST00000375251Q5JVS0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205510492010Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22.21
125051512003Characterization of a new family of proteins that interact with the C-terminal region of the chromatin-remodeling factor CHD-3.20
146991382004Ki-1/57 interacts with RACK1 and is a substrate for the phosphorylation by phorbol 12-myristate 13-acetate-activated protein kinase C.10
168796142006Ki-1/57 interacts with PRMT1 and is a substrate for arginine methylation.10
187887742008Human regulatory protein Ki-1/57 has characteristics of an intrinsically unstructured protein.8
217715942011Evidence for the association of the human regulatory protein Ki-1/57 with the translational machinery.7
158622992005MEF2C DNA-binding activity is inhibited through its interaction with the regulatory protein Ki-1/57.4
195231142009Functional association of human Ki-1/57 with pre-mRNA splicing events.4
204362792010From protein interaction profile to functional assignment: the human protein Ki-1/57 is associated with pre-mRNA splicing events.2
286957422017Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.2

Citation

Dessen P

HABP4 (hyaluronan binding protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52360/habp4