HAMP (hepcidin antimicrobial peptide)

2008-08-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
HEPC,HFE2B,LEAP1,PLTR

Other Information

Locus ID:

NCBI: 57817
MIM: 606464
HGNC: 15598
Ensembl: ENSG00000105697

Variants:

dbSNP: 57817
ClinVar: 57817
TCGA: ENSG00000105697
COSMIC: HAMP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105697ENST00000222304P81172
ENSG00000105697ENST00000598398P81172

Expression (GTEx)

0
100
200
300
400
500
600

References

Pubmed IDYearTitleCitations
155141162004Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.1179
151240182004IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.608
124336762003Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.319
126634372003Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation.273
110343172000LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity.247
168353722006Interleukin-6 induces hepcidin expression through STAT3.239
177215442007High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin.229
213462502011Hepcidin and iron regulation, 10 years later.227
169462982007STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation.173
124691202003Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis.168

Citation

Dessen P

HAMP (hepcidin antimicrobial peptide)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50294/hamp