HAS3 (hyaluronan synthase 3)

2007-02-01 Affiliation

Identity

HGNC

HAS3

LOCATION

16q22.1

LOCUSID

3038

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3038
MIM: 602428
HGNC: 4820
Ensembl: ENSG00000103044

Variants:

dbSNP: 3038
ClinVar: 3038
TCGA: ENSG00000103044
COSMIC: HAS3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103044	ENST00000219322	O00219
ENSG00000103044	ENST00000306560	O00219
ENSG00000103044	ENST00000566118	H3BRH5
ENSG00000103044	ENST00000569188	O00219

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism	REACTOME	R-HSA-1430728
Metabolism of carbohydrates	REACTOME	R-HSA-71387
Glycosaminoglycan metabolism	REACTOME	R-HSA-1630316
Hyaluronan metabolism	REACTOME	R-HSA-2142845
Hyaluronan biosynthesis and export	REACTOME	R-HSA-2142850

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA130620651	anthracyclines and related substances	Chemical	ClinicalAnnotation	associated		PD
PA445018	Cardiomyopathies	Disease	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
24470002	2014	Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.	36
25147816	2014	Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.	31
21429221	2011	Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.	30
11790779	2002	Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells.	28
23303191	2013	Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.	27
19435493	2009	Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content.	20
14566823	2003	Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth.	17
20875124	2010	Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.	15
24658508	2014	Hyaluronan metabolism in human keratinocytes and atopic dermatitis skin is driven by a balance of hyaluronan synthases 1 and 3.	15

Citation

Dessen P

HAS3 (hyaluronan synthase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46583/has3