HAUS6 (HAUS augmin like complex subunit 6)

2014-11-01  

Identity

HGNC
LOCATION
9p22.1
LOCUSID
ALIAS
Dgt6,FAM29A
FUSION GENES

Other Information

Locus ID:

NCBI: 54801
MIM: 613433
HGNC: 25948
Ensembl: ENSG00000147874

Variants:

dbSNP: 54801
ClinVar: 54801
TCGA: ENSG00000147874
COSMIC: HAUS6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147874ENST00000380496Q5VY60
ENSG00000147874ENST00000380502Q7Z4H7
ENSG00000147874ENST00000415524Q5SYF9

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
184432202008Augmin: a protein complex required for centrosome-independent microtubule generation within the spindle.139
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190293372008FAM29A promotes microtubule amplification via recruitment of the NEDD1-gamma-tubulin complex to the mitotic spindle.45
251739752014Reconstitution of the augmin complex provides insights into its architecture and function.20
311138242019Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth.8

Citation

Dessen P

HAUS6 (HAUS augmin like complex subunit 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64178/haus6