Identity
HGNC
LOCATION
3q13.33
LOCUSID
ALIAS
CTTNL,HS1,lckBP1,p75
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3059
MIM: 601306
HGNC: 4844
Ensembl: ENSG00000180353
Variants:
dbSNP: 3059
ClinVar: 3059
TCGA: ENSG00000180353
COSMIC: HCLS1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 30537294 | 2019 | Hematopoietic cell-specific lyn substrate (HCLS1 or HS1): A versatile actin-binding protein in leukocytes. | 13 |
| 30537294 | 2019 | Hematopoietic cell-specific lyn substrate (HCLS1 or HS1): A versatile actin-binding protein in leukocytes. | 13 |
| 28465529 | 2017 | Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells. | 32 |
| 28465529 | 2017 | Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells. | 32 |
| 25359136 | 2015 | SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. | 6 |
| 25359136 | 2015 | SDF1α-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells. | 6 |
| 23017497 | 2013 | Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. | 1 |
| 23017497 | 2013 | Phosphoproteome analyses reveal specific implications of Hcls1, p21-activated kinase 1 and Ezrin in proliferation of a myeloid progenitor cell line downstream of wild-type and ITD mutant Fms-like tyrosine kinase 3 receptors. | 1 |
| 21287358 | 2012 | The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. | 0 |
| 22333038 | 2012 | High expression of hematopoietic cell specific Lyn substrate-1 (HS1) predicts poor survival of B-cell chronic lymphocytic leukemia patients. | 9 |
| 22679023 | 2012 | The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. | 21 |
| 22768161 | 2012 | HS1, a Lyn kinase substrate, is abnormally expressed in B-chronic lymphocytic leukemia and correlates with response to fludarabine-based regimen. | 14 |
| 23001182 | 2012 | Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. | 39 |
| 21287358 | 2012 | The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs. | 0 |
| 22333038 | 2012 | High expression of hematopoietic cell specific Lyn substrate-1 (HS1) predicts poor survival of B-cell chronic lymphocytic leukemia patients. | 9 |
Citation
Dessen P
HCLS1 (hematopoietic cell-specific Lyn substrate 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46153/hcls1
