HCRT (hypocretin neuropeptide precursor)

2015-09-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
NRCLP1,OX,PPOX

Other Information

Locus ID:

NCBI: 3060
MIM: 602358
HGNC: 4847
Ensembl: ENSG00000161610

Variants:

dbSNP: 3060
ClinVar: 3060
TCGA: ENSG00000161610
COSMIC: HCRT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161610ENST00000293330O43612

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Orexin and neuropeptides FF and QRFP bind to their respective receptorsREACTOMER-HSA-389397
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195499262009Orexin/hypocretin: a neuropeptide at the interface of sleep, energy homeostasis, and reward system.126
198745742009Genetical genomic determinants of alcohol consumption in rats and humans.93
234629902013Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.76
203056452010Monitoring neural activity with bioluminescence during natural behavior.64
128737982003Diurnal variation of cerebrospinal fluid hypocretin-1 (Orexin-A) levels in control and depressed subjects.60
215461242012Hypocretin (orexin) loss in Alzheimer's disease.50
198479032009Loss of hypocretin (orexin) neurons with traumatic brain injury.43
230343872013Physiology of the orexinergic/hypocretinergic system: a revisit in 2012.36
204680642010Association study of 182 candidate genes in anorexia nervosa.30
245994602014Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock.29

Citation

Dessen P

HCRT (hypocretin neuropeptide precursor)

Atlas Genet Cytogenet Oncol Haematol. 2015-09-01

Online version: http://atlasgeneticsoncology.org/gene/55398/hcrt