HDAC11 (histone deacetylase 11)

2007-02-01  

Identity

HGNC
LOCATION
3p25.1
LOCUSID
ALIAS
HD11
FUSION GENES

Other Information

Locus ID:

NCBI: 79885
MIM: 607226
HGNC: 19086
Ensembl: ENSG00000163517

Variants:

dbSNP: 79885
ClinVar: 79885
TCGA: ENSG00000163517
COSMIC: HDAC11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163517ENST00000295757Q96DB2
ENSG00000163517ENST00000295757A0A024R2I1
ENSG00000163517ENST00000402259B5MCS3
ENSG00000163517ENST00000402271B5MCQ6
ENSG00000163517ENST00000404040B5MCU6
ENSG00000163517ENST00000404548B5MC52
ENSG00000163517ENST00000405025B5MD06
ENSG00000163517ENST00000405478B5MCV5
ENSG00000163517ENST00000416248C9JMH0
ENSG00000163517ENST00000418189C9J528
ENSG00000163517ENST00000425430F8WF94
ENSG00000163517ENST00000433119Q658J9
ENSG00000163517ENST00000434848C9JBI4
ENSG00000163517ENST00000437379E7ETT9
ENSG00000163517ENST00000446613Q658J9
ENSG00000163517ENST00000455904C9JEC8
ENSG00000163517ENST00000522202Q96DB2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451846valproic acidChemicalPathwayassociated23407051

References

Pubmed IDYearTitleCitations
119481782002Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family.175
190116282009The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance.130
212396962011HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma.35
230240012013HDAC11 is a novel drug target in carcinomas.32
192760812009Acetylation/deacetylation modulates the stability of DNA replication licensing factor Cdt1.30
209808342010Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin.29
204673342010Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis.27
218063502012Increased gene expression of histone deacetylases in patients with Philadelphia-negative chronic myeloproliferative neoplasms.20
293365432018Histone Deacetylase 11 Is a Fatty-Acid Deacylase.20
161423912005Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene.15

Citation

Dessen P

HDAC11 (histone deacetylase 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46206/hdac11