Identity
HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
AHO3,BDMR,HA6116,HD4,HDAC-4,HDAC-A,HDACA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9759
MIM: 605314
HGNC: 14063
Ensembl: ENSG00000068024
Variants:
dbSNP: 9759
ClinVar: 9759
TCGA: ENSG00000068024
COSMIC: HDAC4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA451609 | temozolomide | Chemical | MultilinkAnnotation | associated | 24444404 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38057370 | 2024 | Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease. | 0 |
| 38217540 | 2024 | ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis. | 0 |
| 38281192 | 2024 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. | 0 |
| 38057370 | 2024 | Targeting SIK3 to modulate hippocampal synaptic plasticity and cognitive function by regulating the transcription of HDAC4 in a mouse model of Alzheimer's disease. | 0 |
| 38217540 | 2024 | ZIP4 upregulation aggravates nucleus pulposus cell degradation by promoting inflammation and oxidative stress by mediating the HDAC4-FoxO3a axis. | 0 |
| 38281192 | 2024 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation. | 0 |
| 37010483 | 2023 | WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis. | 3 |
| 37013891 | 2023 | Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients. | 1 |
| 37052456 | 2023 | Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591. | 1 |
| 37096653 | 2023 | LncRNA CASC11 upregulation promotes HDAC4 to alleviate oxidized low-density lipoprotein-induced injury of cardiac microvascular endothelial cells. | 1 |
| 37711168 | 2023 | Candidate Oligo Therapeutic Target, miR-330-3p, Induces Tamoxifen Resistance in Estrogen Receptor-Positive Breast Cancer Cells via HDAC4. | 0 |
| 37769062 | 2023 | HDAC4 regulates the proliferation, migration, and invasion of trophoblasts in pre-eclampsia through the miR-134-5p/FOXM1 axis. | 0 |
| 38031987 | 2023 | Association between circHIPK3/miR-378a-3p/HDAC4 axis and osteoporotic fractures: A comprehensive investigation. | 1 |
| 37010483 | 2023 | WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis. | 3 |
| 37013891 | 2023 | Circulating HDAC4 reflects lipid profile, coronary stenosis and inflammation in coronary heart disease patients. | 1 |
Citation
Dessen P
HDAC4 (histone deacetylase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40805/hdac4
