HDAC5 (histone deacetylase 5)

2003-05-01  

Identity

HGNC
HDAC5
LOCATION
17q21.31
LOCUSID
10014
ALIAS
HD5,NY-CO-9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10014
MIM: 605315
HGNC: 14068
Ensembl: ENSG00000108840

Variants:

dbSNP: 10014
ClinVar: 10014
TCGA: ENSG00000108840
COSMIC: HDAC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108840ENST00000225983Q9UQL6
ENSG00000108840ENST00000336057Q9UQL6
ENSG00000108840ENST00000586802Q9UQL6
ENSG00000108840ENST00000587135K7EJZ7
ENSG00000108840ENST00000588261K7EJL4
ENSG00000108840ENST00000588703K7EJL6
ENSG00000108840ENST00000591714K7ES01

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Epstein-Barr virus infectionKEGGhsa05169
AlcoholismKEGGhsa05034
Epstein-Barr virus infectionKEGGko05169
AlcoholismKEGGko05034
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by NOTCH1 in CancerREACTOMER-HSA-2644603
Signaling by NOTCH1 PEST Domain Mutants in CancerREACTOMER-HSA-2644602
Constitutive Signaling by NOTCH1 PEST Domain MutantsREACTOMER-HSA-2644606
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerREACTOMER-HSA-2894858
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsREACTOMER-HSA-2894862
Signal TransductionREACTOMER-HSA-162582
Signaling by NOTCHREACTOMER-HSA-157118
Signaling by NOTCH1REACTOMER-HSA-1980143
NOTCH1 Intracellular Domain Regulates TranscriptionREACTOMER-HSA-2122947
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
181849302008AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5.117
122423052002Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation.94
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
183321342008Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.78
200427202010Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.69
151947492004Functional interaction between class II histone deacetylases and ICP0 of herpes simplex virus type 1.65
182189812008Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure.62
119298732002Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor.55
193519562009HDAC5 is a repressor of angiogenesis and determines the angiogenic gene expression pattern of endothelial cells.55
210816662011Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation.53

Citation

Dessen P

HDAC5 (histone deacetylase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40806/hdac5