Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23072
MIM: 610384
HGNC: 22195
Ensembl: ENSG00000002746
Variants:
dbSNP: 23072
ClinVar: 23072
TCGA: ENSG00000002746
COSMIC: HECW1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000002746 | ENST00000395891 | Q76N89 |
| ENSG00000002746 | ENST00000429529 | H7C3Q2 |
| ENSG00000002746 | ENST00000453890 | Q76N89 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36674783 | 2023 | Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1. | 0 |
| 38049396 | 2023 | HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350. | 0 |
| 36674783 | 2023 | Study of Ubiquitin Pathway Genes in a French Population with Amyotrophic Lateral Sclerosis: Focus on HECW1 Encoding the E3 Ligase NEDL1. | 0 |
| 38049396 | 2023 | HECW1 induces NCOA4-regulated ferroptosis in glioma through the ubiquitination and degradation of ZNF350. | 0 |
| 33529121 | 2021 | E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4. | 9 |
| 34348693 | 2021 | Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma. | 6 |
| 33529121 | 2021 | E3 ubiquitin ligase HECW1 promotes the metastasis of non-small cell lung cancer cells through mediating the ubiquitination of Smad4. | 9 |
| 34348693 | 2021 | Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma. | 6 |
| 30849519 | 2019 | The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. | 5 |
| 31057023 | 2019 | Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy. | 5 |
| 30849519 | 2019 | The E3 ubiquitin ligase HECW1 targets thyroid transcription factor 1 (TTF1/NKX2.1) for its degradation in the ubiquitin-proteasome system. | 5 |
| 31057023 | 2019 | Changes E3 ubiquitin protein ligase 1 gene mRNA expression correlated with IgA1 glycosylation in patients with IgA nephropathy. | 5 |
| 26880200 | 2016 | Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. | 44 |
| 26880200 | 2016 | Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. | 44 |
| 20976258 | 2011 | Muscle atrophy and motor neuron degeneration in human NEDL1 transgenic mice. | 17 |
Citation
Dessen P
HECW1 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47474/hecw1
