HEMGN (hemogen)

2007-02-01  

Identity

HGNC
LOCATION
9q22.33
LOCUSID
ALIAS
CT155,EDAG,EDAG-1,NDR
FUSION GENES

Other Information

Locus ID:

NCBI: 55363
MIM: 610715
HGNC: 17509
Ensembl: ENSG00000136929

Variants:

dbSNP: 55363
ClinVar: 55363
TCGA: ENSG00000136929
COSMIC: HEMGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136929ENST00000259456Q9BXL5
ENSG00000136929ENST00000259456A0A024R162
ENSG00000136929ENST00000616898Q9BXL5
ENSG00000136929ENST00000616898A0A024R162

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197790222009FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate.57
153321172004EDAG regulates the proliferation and differentiation of hematopoietic cells and resists cell apoptosis through the activation of nuclear factor-kappa B.15
247409102014EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300.9
185993892008Suppression of EDAG gene expression by phorbol 12-myristate 13-acetate is mediated through down-regulation of GATA-1.6
164371492006The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells.5
205641852010Over-expression of EDAG in the myeloid cell line 32D: induction of GATA-1 expression and erythroid/megakaryocytic phenotype.5
227125022012Erythroid differentiation-associated gene interacts with NPM1 (nucleophosmin/B23) and increases its protein stability, resisting cell apoptosis.4
147302142004Down-regulation of human NDR gene in megakaryocytic differentiation of erythroleukemia K562 cells.2
176717162007Down-regulation of EDAG expression by retrovirus-mediated small interfering RNA inhibits the growth and IL-8 production of leukemia cells.2
272615812016Embryonic develop-associated gene 1 is overexpressed and acts as a tumor promoter in thyroid carcinoma.1

Citation

Dessen P

HEMGN (hemogen)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45870/hemgn