Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51191
MIM: 608242
HGNC: 24368
Ensembl: ENSG00000138646
Variants:
dbSNP: 51191
ClinVar: 51191
TCGA: ENSG00000138646
COSMIC: HERC5
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138646 | ENST00000264350 | Q9UII4 |
| ENSG00000138646 | ENST00000508159 | E9PBL0 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38605423 | 2024 | HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis. | 1 |
| 38605423 | 2024 | HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis. | 1 |
| 37279284 | 2023 | The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN. | 0 |
| 37651190 | 2023 | Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. | 2 |
| 37279284 | 2023 | The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN. | 0 |
| 37651190 | 2023 | Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation. | 2 |
| 35671810 | 2022 | HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration. | 2 |
| 35671810 | 2022 | HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration. | 2 |
| 34147029 | 2021 | Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells. | 6 |
| 34661519 | 2021 | HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication. | 6 |
| 34147029 | 2021 | Downregulation of HERC5 E3 ligase attenuates the ubiquitination of CtBP1 to inhibit apoptosis in colorectal cancer cells. | 6 |
| 34661519 | 2021 | HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication. | 6 |
| 31225658 | 2020 | Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer. | 27 |
| 31225658 | 2020 | Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer. | 27 |
| 29669830 | 2018 | Evolution-Guided Structural and Functional Analyses of the HERC Family Reveal an Ancient Marine Origin and Determinants of Antiviral Activity. | 20 |
Citation
Dessen P
HERC5 (HECT and RLD domain containing E3 ubiquitin protein ligase 5)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/46681/herc5
