HES3 (hes family bHLH transcription factor 3)

2016-12-01  

Identity

HGNC
HES3
LOCATION
1p36.31
LOCUSID
390992
ALIAS
bHLHb43

Other Information

Locus ID:

NCBI: 390992
MIM: 609971
HGNC: 26226
Ensembl: ENSG00000173673

Variants:

dbSNP: 390992
ClinVar: 390992
TCGA: ENSG00000173673
COSMIC: HES3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173673ENST00000377898Q5TGS1

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
181624672008Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence.19
267837392016STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?2
233936142013Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics.0
245125682014Expression of the transcription factor Hes3 in the mouse and human ocular surface, and in pterygium.0
253712012014Hes3 is expressed in the adult pancreatic islet and regulates gene expression, cell growth, and insulin release.0
298696122018PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis.0
309112812019Hes3 Enhances the Malignant Phenotype of Lung Cancer through Upregulating Cyclin D1, Cyclin D3 and MMP7 Expression.0

Citation

Dessen P

HES3 (hes family bHLH transcription factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56659/hes3