HES6 (hes family bHLH transcription factor 6)

2003-05-01  

Identity

HGNC
LOCATION
2q37.3
LOCUSID
ALIAS
C-HAIRY1,HES-6,bHLHb41,bHLHc23
FUSION GENES

Other Information

Locus ID:

NCBI: 55502
MIM: 610331
HGNC: 18254
Ensembl: ENSG00000144485

Variants:

dbSNP: 55502
ClinVar: 55502
TCGA: ENSG00000144485
COSMIC: HES6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144485ENST00000272937Q96HZ4
ENSG00000144485ENST00000409002Q96HZ4
ENSG00000144485ENST00000409160Q96HZ4
ENSG00000144485ENST00000409182B9A070
ENSG00000144485ENST00000409356B8ZZP9
ENSG00000144485ENST00000409574Q96HZ4
ENSG00000144485ENST00000417803H7C1R4
ENSG00000144485ENST00000436051H7C020
ENSG00000144485ENST00000450098C9JF41

Expression (GTEx)

0
10
20
30
40
50
60
70

References

Pubmed IDYearTitleCitations
129726102003Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.45
173010322007Impaired expression of Notch signaling genes in aged human skeletal muscle.29
247378702014HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.26
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
178267722007Gene expression profiling identifies Hes6 as a transcriptional target of ATOH1 in cochlear hair cells.11
198917872009Hes-6, an inhibitor of Hes-1, is regulated by 17beta-estradiol and promotes breast cancer cell proliferation.11
217854612012HES6 gene is selectively overexpressed in glioma and represents an important transcriptional regulator of glioma proliferation.11
158962952005The conserved WRPW motif of Hes6 mediates proteasomal degradation.7
173007532007HES6 reverses nuclear reprogramming of insulin-producing cells following cell fusion.7
129573622003Detection of differentially expressed HES-6 gene in metastatic colon carcinoma by combination of suppression subtractive hybridization and cDNA library array.5

Citation

Dessen P

HES6 (hes family bHLH transcription factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40813/hes6