HES6 (hes family bHLH transcription factor 6)

2003-05-01  

Identity

HGNC
HES6
LOCATION
2q37.3
LOCUSID
55502
ALIAS
C-HAIRY1,HES-6,bHLHb41,bHLHc23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55502
MIM: 610331
HGNC: 18254
Ensembl: ENSG00000144485

Variants:

dbSNP: 55502
ClinVar: 55502
TCGA: ENSG00000144485
COSMIC: HES6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144485ENST00000272937Q96HZ4
ENSG00000144485ENST00000409002Q96HZ4
ENSG00000144485ENST00000409160Q96HZ4
ENSG00000144485ENST00000409182B9A070
ENSG00000144485ENST00000409356B8ZZP9
ENSG00000144485ENST00000409574Q96HZ4
ENSG00000144485ENST00000417803H7C1R4
ENSG00000144485ENST00000436051H7C020
ENSG00000144485ENST00000450098C9JF41

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
369294212023The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis.2
369294212023The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis.2
359348442022ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.1
359348442022ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.1
334624062021Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.38
334624062021Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease.38
300159092018Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer.7
300159092018Overexpression of HES6 has prognostic value and promotes metastasis via the Wnt/β-catenin signaling pathway in colorectal cancer.7
258645182015HES6 promotes prostate cancer aggressiveness independently of Notch signalling.10
258645182015HES6 promotes prostate cancer aggressiveness independently of Notch signalling.10
247378702014HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.0
250061832014DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.8
247378702014HES6 drives a critical AR transcriptional programme to induce castration-resistant prostate cancer through activation of an E2F1-mediated cell cycle network.0
250061832014DOT1L-HES6 fusion drives androgen independent growth in prostate cancer.8
229827282013HES6 enhances the motility of alveolar rhabdomyosarcoma cells.6

Citation

Dessen P

HES6 (hes family bHLH transcription factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40813/hes6