Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23493
MIM: 604674
HGNC: 4881
Ensembl: ENSG00000135547
Variants:
dbSNP: 23493
ClinVar: 23493
TCGA: ENSG00000135547
COSMIC: HEY2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135547 | ENST00000368364 | Q9UBP5 |
| ENSG00000135547 | ENST00000368365 | Q5TF93 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32820247 | 2021 | Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms. | 8 |
| 32820247 | 2021 | Germline variants in HEY2 functional domains lead to congenital heart defects and thoracic aortic aneurysms. | 8 |
| 31565805 | 2020 | microRNA-599 promotes apoptosis and represses proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells via downregulation of Hey2-depentent Notch signaling pathway. | 18 |
| 32712748 | 2020 | TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma. | 4 |
| 32997309 | 2020 | Notch-HEY2 signaling pathway contributes to the differentiation of CD34(+) hematopoietic-like stem cells from adult peripheral blood insulin-producing cells after the treatment with platelet-derived mitochondria. | 0 |
| 31565805 | 2020 | microRNA-599 promotes apoptosis and represses proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells via downregulation of Hey2-depentent Notch signaling pathway. | 18 |
| 32712748 | 2020 | TWIST1 correlates with Notch signaling pathway to develop esophageal squamous cell carcinoma. | 4 |
| 32997309 | 2020 | Notch-HEY2 signaling pathway contributes to the differentiation of CD34(+) hematopoietic-like stem cells from adult peripheral blood insulin-producing cells after the treatment with platelet-derived mitochondria. | 0 |
| 30125982 | 2019 | microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. | 9 |
| 31255287 | 2019 | Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. | 8 |
| 30125982 | 2019 | microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. | 9 |
| 31255287 | 2019 | Attenuation of PRRX2 and HEY2 enables efficient conversion of adult human skin fibroblasts to neurons. | 8 |
| 29636455 | 2018 | NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. | 50 |
| 30257372 | 2018 | LncRNA PRNCR1 interacts with HEY2 to abolish miR-448-mediated growth inhibition in non-small cell lung cancer. | 14 |
| 29636455 | 2018 | NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. | 50 |
Citation
Dessen P
HEY2 (hes related family bHLH transcription factor with YRPW motif 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/47515/hey2
