HHIP (hedgehog interacting protein)

2007-02-01  

Identity

HGNC
HHIP
LOCATION
4q31.21
LOCUSID
64399
ALIAS
HIP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64399
MIM: 606178
HGNC: 14866
Ensembl: ENSG00000164161

Variants:

dbSNP: 64399
ClinVar: 64399
TCGA: ENSG00000164161
COSMIC: HHIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164161ENST00000296575Q96QV1
ENSG00000164161ENST00000434550Q96QV1

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Basal cell carcinomaKEGGko05217
Hedgehog signaling pathwayKEGGhsa04340
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684
Ligand-receptor interactionsREACTOMER-HSA-5632681

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
183919522008Genome-wide association analysis identifies 20 loci that influence adult height.322
193004822009A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.302
193004822009A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.302
200108352010Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.251
199155942009Modulating hedgehog signaling can attenuate the severity of osteoarthritis.117
221400902012Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
213979372011Importance of hedgehog interacting protein and other lung function genes in asthma.61
195616092009The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.58
206569432010Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.55

Citation

Dessen P

HHIP (hedgehog interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43958/hhip