Identity
HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
HIF-1-alpha,HIF-1A,HIF-1alpha,HIF1,HIF1-ALPHA,MOP1,PASD8,bHLHe78
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3091
MIM: 603348
HGNC: 4910
Ensembl: ENSG00000100644
Variants:
dbSNP: 3091
ClinVar: 3091
TCGA: ENSG00000100644
COSMIC: HIF1A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164924493 | axitinib | Chemical | ClinicalAnnotation | associated | PD | 25816720 | |
| PA7000 | sorafenib | Chemical | ClinicalAnnotation | associated | PD | 25816720 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35762928 | 2024 | Effect of HIF-1α on estrogen/ERα signaling pathway in pituitary adenoma cells in hypoxic environment. | 0 |
| 36385451 | 2024 | Aerobic Glycolysis Induced by mTOR/HIF-1α Promotes Early Brain Injury After Subarachnoid Hemorrhage via Activating M1 Microglia. | 6 |
| 37158785 | 2024 | Human ESC-derived vascular cells promote vascular regeneration in a HIF-1α dependent manner. | 1 |
| 37392242 | 2024 | The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients. | 0 |
| 37552389 | 2024 | The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies. | 4 |
| 37733267 | 2024 | Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A/HIF-1α transcriptional complex. | 3 |
| 37786269 | 2024 | HIF-1α Contributes to Hypoxia-induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection. | 1 |
| 37832842 | 2024 | Apolipoprotein A-I Binding Protein Inhibits the Formation of Infantile Hemangioma through Cholesterol-Regulated Hypoxia-Inducible Factor 1α Activation. | 0 |
| 37884162 | 2024 | The SNHG10-miR-495-3p-PTEN axis is involved in sevoflurane-mediated protective effects in cardiomyocytes against hypoxia/reoxygenation injury. | 0 |
| 37952104 | 2024 | Nicotinamide Riboside Modulates HIF-1 Signaling to Maintain and Enhance Odontoblastic Differentiation in Human Dental Pulp Stem Cells. | 0 |
| 37957027 | 2024 | Overexpression of VEGFA mediated by HIF-1 is associated with higher rate of spread through air spaces in resected lung adenocarcinomas. | 0 |
| 37983895 | 2024 | Hypoxia-induced factor-1α promotes radioresistance of esophageal cancer cells by transcriptionally activating LINC01116 and suppressing miR-3612 under hypoxia. | 0 |
| 38013127 | 2024 | LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis. | 0 |
| 38019129 | 2024 | IL-17A Orchestrates Reactive Oxygen Species/HIF1α-Mediated Metabolic Reprogramming in Psoriasis. | 2 |
| 38037834 | 2024 | KIF20A Promotes CRC Progression and the Warburg Effect through the C-Myc/HIF-1α Axis. | 0 |
Citation
Dessen P
HIF1A (hypoxia inducible factor 1 subunit alpha)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/40821/hif1a
