HIGD1A (HIG1 hypoxia inducible domain family member 1A)

2007-04-01  

Identity

HGNC
LOCATION
3p22.1
LOCUSID
ALIAS
HIG1,RCF1a
FUSION GENES

Other Information

Locus ID:

NCBI: 25994
MIM: 618623
HGNC: 29527
Ensembl: ENSG00000181061

Variants:

dbSNP: 25994
ClinVar: 25994
TCGA: ENSG00000181061
COSMIC: HIGD1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181061ENST00000321331Q9Y241
ENSG00000181061ENST00000321331A0A024R2M9
ENSG00000181061ENST00000418900Q9Y241
ENSG00000181061ENST00000418900A0A024R2M9
ENSG00000181061ENST00000430190C9JNU6
ENSG00000181061ENST00000452906Q9Y241

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Regulation of gene expression by Hypoxia-inducible FactorREACTOMER-HSA-1234158

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
238782412013Higd-1a interacts with Opa1 and is required for the morphological and functional integrity of mitochondria.13
236461412013Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress.10
223551942012HIG1, a novel regulator of mitochondrial γ-secretase, maintains normal mitochondrial function.9
310894102019Higd1a Protects Cells from Lipotoxicity under High-Fat Exposure.2
313107992019Higd-1a regulates the proliferation of pancreatic cancer cells through a pERK/p27KIP1/pRB pathway.1

Citation

Dessen P

HIGD1A (HIG1 hypoxia inducible domain family member 1A)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46646/higd1a