HIKESHI (heat shock protein nuclear import factor hikeshi)

2018-07-01  

Identity

HGNC
LOCATION
11q14.2
LOCUSID
ALIAS
C11orf73,HLD13,HSPC138,HSPC179,L7RN6,OPI10

Other Information

Locus ID:

NCBI: 51501
MIM: 614908
HGNC: 26938
Ensembl: ENSG00000149196

Variants:

dbSNP: 51501
ClinVar: 51501
TCGA: ENSG00000149196
COSMIC: HIKESHI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149196ENST00000278483Q53FT3
ENSG00000149196ENST00000528004E9PJB2
ENSG00000149196ENST00000533986E9PPG8
ENSG00000149196ENST00000618164A0A087WYW7

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
225414292012Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage.34
265458782016Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene.7
257605972015Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s.1
287311752017Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.1
289807482017Hikeshi modulates the proteotoxic stress response in human cells: Implication for the importance of the nuclear function of HSP70s.1
280006992017Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.0

Citation

Dessen P

HIKESHI (heat shock protein nuclear import factor hikeshi)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57496/hikeshi