HINT2 (histidine triad nucleotide binding protein 2)

2014-02-01  

Identity

HGNC
HINT2
LOCATION
9p13.3
LOCUSID
84681
ALIAS
HIT-17

Other Information

Locus ID:

NCBI: 84681
MIM: 609997
HGNC: 18344
Ensembl: ENSG00000137133

Variants:

dbSNP: 84681
ClinVar: 84681
TCGA: ENSG00000137133
COSMIC: HINT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137133ENST00000259667Q9BX68

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
236820762013Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells.17
289471372017HINT2 triggers mitochondrial Ca2+ influx by regulating the mitochondrial Ca2+ uniporter (MCU) complex and enhances gemcitabine apoptotic effect in pancreatic cancer.9
186537182008Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis.7
236596322013Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.6
280887872017HINT2 downregulation promotes colorectal carcinoma migration and metastasis.4
299135632018The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism.2
317701972019Clinical significance of down-regulated HINT2 in hepatocellular carcinoma.0

Citation

Dessen P

HINT2 (histidine triad nucleotide binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-02-01

Online version: http://atlasgeneticsoncology.org/gene/53805/hint2