HJURP (Holliday junction recognition protein)

2007-11-01  

Identity

HGNC
HJURP
LOCATION
2q37.1
LOCUSID
55355
ALIAS
FAKTS,URLC9,hFLEG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55355
MIM: 612667
HGNC: 25444
Ensembl: ENSG00000123485

Variants:

dbSNP: 55355
ClinVar: 55355
TCGA: ENSG00000123485
COSMIC: HJURP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123485ENST00000411486Q8NCD3
ENSG00000123485ENST00000414924C9JWC4
ENSG00000123485ENST00000432087Q8NCD3
ENSG00000123485ENST00000433484H7C0I6
ENSG00000123485ENST00000441687Q8NCD3
ENSG00000123485ENST00000453122F8WCV1
ENSG00000123485ENST00000454020H7C3V8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
166224192006The human CENP-A centromeric nucleosome-associated complex.295
194105442009Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.256
194105452009HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.238
217682892011HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore.136
200805772010HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres.85
214782742011Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP.84
202110172010The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancer.62
251174892014A long non-coding RNA is required for targeting centromeric protein A to the human centromere.57
237710582013Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition.34
219803052011Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells.33

Citation

Dessen P

HJURP (Holliday junction recognition protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-11-01

Online version: http://atlasgeneticsoncology.org/gene/49810/hjurp