HK3 (hexokinase 3)

2007-04-01  

Identity

HGNC
HK3
LOCATION
5q35.2
LOCUSID
3101
ALIAS
HKIII,HXK3

Other Information

Locus ID:

NCBI: 3101
MIM: 142570
HGNC: 4925
Ensembl: ENSG00000160883

Variants:

dbSNP: 3101
ClinVar: 3101
TCGA: ENSG00000160883
COSMIC: HK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160883ENST00000292432P52790
ENSG00000160883ENST00000292432A0A024R7R1
ENSG00000160883ENST00000504910H0YAG4
ENSG00000160883ENST00000509717H0Y8U9
ENSG00000160883ENST00000514058H0Y9N6

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Fructose and mannose metabolismKEGGko00051
Galactose metabolismKEGGko00052
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Insulin signaling pathwayKEGGko04910
Type II diabetes mellitusKEGGko04930
Glycolysis / GluconeogenesisKEGGhsa00010
Fructose and mannose metabolismKEGGhsa00051
Galactose metabolismKEGGhsa00052
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Insulin signaling pathwayKEGGhsa04910
Type II diabetes mellitusKEGGhsa04930
Metabolic pathwaysKEGGhsa01100
Neomycin, kanamycin and gentamicin biosynthesisKEGGko00524
Neomycin, kanamycin and gentamicin biosynthesisKEGGhsa00524
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGhsa_M00549
Nucleotide sugar biosynthesis, glucose => UDP-glucoseKEGGM00549
HIF-1 signaling pathwayKEGGhsa04066
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Central carbon metabolism in cancerKEGGhsa05230
Central carbon metabolism in cancerKEGGko05230
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Hexose transportREACTOMER-HSA-189200
Glucose transportREACTOMER-HSA-70153
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194486212009Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.142
224987382012PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
210722052010Regulation and cytoprotective role of hexokinase III.16
295049072018HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer.14
245848572014CEBPA-dependent HK3 and KLF5 expression in primary AML and during AML differentiation.7
268559922015[Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods].7
280052672017Human gingiva transcriptome during wound healing.6
178684002008Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.5
195545042009Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma.4

Citation

Dessen P

HK3 (hexokinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46641/hk3