HLA-DOB (major histocompatibility complex, class II, DO beta)

2007-02-01  

Identity

HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
DOB,HLA_DOB
FUSION GENES

Other Information

Locus ID:

NCBI: 3112
MIM: 600629
HGNC: 4937
Ensembl: ENSG00000241106

Variants:

dbSNP: 3112
ClinVar: 3112
TCGA: ENSG00000241106
COSMIC: HLA-DOB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241106ENST00000438763P13765
ENSG00000241106ENST00000438763Q5QNS2
ENSG00000241106ENST00000447394H0Y4X4
ENSG00000241106ENST00000488325E9PI00
ENSG00000241106ENST00000648009P13765
ENSG00000241106ENST00000648009Q5QNS2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Antigen processing and presentationKEGGko04612
Hematopoietic cell lineageKEGGko04640
Type I diabetes mellitusKEGGko04940
AsthmaKEGGko05310
Autoimmune thyroid diseaseKEGGko05320
Systemic lupus erythematosusKEGGko05322
Allograft rejectionKEGGko05330
Graft-versus-host diseaseKEGGko05332
Cell adhesion molecules (CAMs)KEGGhsa04514
Antigen processing and presentationKEGGhsa04612
Hematopoietic cell lineageKEGGhsa04640
Type I diabetes mellitusKEGGhsa04940
AsthmaKEGGhsa05310
Autoimmune thyroid diseaseKEGGhsa05320
Systemic lupus erythematosusKEGGhsa05322
Allograft rejectionKEGGhsa05330
Graft-versus-host diseaseKEGGhsa05332
Viral myocarditisKEGGhsa05416
Intestinal immune network for IgA productionKEGGko04672
Intestinal immune network for IgA productionKEGGhsa04672
LeishmaniasisKEGGko05140
LeishmaniasisKEGGhsa05140
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Staphylococcus aureus infectionKEGGko05150
Staphylococcus aureus infectionKEGGhsa05150
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Influenza AKEGGko05164
Influenza AKEGGhsa05164
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Inflammatory bowel disease (IBD)KEGGhsa05321
Inflammatory bowel disease (IBD)KEGGko05321
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
232226392013HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism.55
198514452009High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions.51
152658822004Ectopic expression of HLA-DO in mouse dendritic cells diminishes MHC class II antigen presentation.30
158476542005A flexible array format for large-scale, rapid blood group DNA typing.30
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
234008682013Ubiquitination of HLA-DO by MARCH family E3 ligases.11
288136602017Neutralizing Antibody Responses to Viral Infections Are Linked to the Non-classical MHC Class II Gene H2-Ob.11
124396222002Novel polymorphisms in HLA-DOA and HLA-DOB in B-cell malignancies.6
258747092015Association of polymorphisms in HLA antigen presentation-related genes with the outcomes of HCV infection.5

Citation

Dessen P

HLA-DOB (major histocompatibility complex, class II, DO beta)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46359/hla-dob