HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)

2008-03-01 Affiliation

Identity

HGNC

HLA-DPB1

LOCATION

6p21.32

LOCUSID

3115

ALIAS

DPB1,HLA-DP,HLA-DP1B,HLA-DPB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3115
MIM: 142858
HGNC: 4940
Ensembl: ENSG00000223865

Variants:

dbSNP: 3115
ClinVar: 3115
TCGA: ENSG00000223865
COSMIC: HLA-DPB1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000223865	ENST00000416804	H0Y5P2
ENSG00000223865	ENST00000418931	P04440
ENSG00000223865	ENST00000418931	I4EC15
ENSG00000223865	ENST00000428835	H0Y7G7

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cell adhesion molecules (CAMs)	KEGG	ko04514
Antigen processing and presentation	KEGG	ko04612
Hematopoietic cell lineage	KEGG	ko04640
Type I diabetes mellitus	KEGG	ko04940
Asthma	KEGG	ko05310
Autoimmune thyroid disease	KEGG	ko05320
Systemic lupus erythematosus	KEGG	ko05322
Allograft rejection	KEGG	ko05330
Graft-versus-host disease	KEGG	ko05332
Cell adhesion molecules (CAMs)	KEGG	hsa04514
Antigen processing and presentation	KEGG	hsa04612
Hematopoietic cell lineage	KEGG	hsa04640
Type I diabetes mellitus	KEGG	hsa04940
Asthma	KEGG	hsa05310
Autoimmune thyroid disease	KEGG	hsa05320
Systemic lupus erythematosus	KEGG	hsa05322
Allograft rejection	KEGG	hsa05330
Graft-versus-host disease	KEGG	hsa05332
Viral myocarditis	KEGG	hsa05416
Intestinal immune network for IgA production	KEGG	ko04672
Intestinal immune network for IgA production	KEGG	hsa04672
Leishmaniasis	KEGG	ko05140
Leishmaniasis	KEGG	hsa05140
Phagosome	KEGG	ko04145
Phagosome	KEGG	hsa04145
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Staphylococcus aureus infection	KEGG	ko05150
Staphylococcus aureus infection	KEGG	hsa05150
Rheumatoid arthritis	KEGG	ko05323
Rheumatoid arthritis	KEGG	hsa05323
Tuberculosis	KEGG	ko05152
Tuberculosis	KEGG	hsa05152
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
HTLV-I infection	KEGG	ko05166
HTLV-I infection	KEGG	hsa05166
Herpes simplex infection	KEGG	ko05168
Herpes simplex infection	KEGG	hsa05168
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
Inflammatory bowel disease (IBD)	KEGG	hsa05321
Inflammatory bowel disease (IBD)	KEGG	ko05321
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
TCR signaling	REACTOME	R-HSA-202403
Phosphorylation of CD3 and TCR zeta chains	REACTOME	R-HSA-202427
Translocation of ZAP-70 to Immunological synapse	REACTOME	R-HSA-202430
Generation of second messenger molecules	REACTOME	R-HSA-202433
Downstream TCR signaling	REACTOME	R-HSA-202424
Costimulation by the CD28 family	REACTOME	R-HSA-388841
PD-1 signaling	REACTOME	R-HSA-389948
MHC class II antigen presentation	REACTOME	R-HSA-2132295
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon gamma signaling	REACTOME	R-HSA-877300
Th1 and Th2 cell differentiation	KEGG	ko04658
Th1 and Th2 cell differentiation	KEGG	hsa04658
Th17 cell differentiation	KEGG	ko04659
Th17 cell differentiation	KEGG	hsa04659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA131285571	aspirin-induced asthma	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	15007363, 9179433
PA443297	Agranulocytosis	Disease	VariantAnnotation	associated	PD	11266078
PA443450	Asthma	Disease	ClinicalAnnotation, VariantAnnotation	associated	PD	15007363, 19392989, 9179433
PA445999	Urticaria	Disease	VariantAnnotation	associated	PD	15784113
PA447216	Schizophrenia	Disease	VariantAnnotation	associated	PD	11266078
PA448497	aspirin	Chemical	ClinicalAnnotation, VariantAnnotation	associated	PD	15007363, 15784113, 19392989, 9179433
PA449061	clozapine	Chemical	VariantAnnotation	associated	PD	11266078

References

Pubmed ID	Year	Title	Citations
17785583	2007	High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.	316
22286218	2012	Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis.	281
19349983	2009	A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.	180
19349983	2009	A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.	180
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
22340965	2012	Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.	80
14508706	2003	HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.	72
17554059	2007	High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism.	72
11984513	2002	HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population.	61
26267621	2015	High HLA-DP Expression and Graft-versus-Host Disease.	61

Citation

Dessen P

HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-03-01

Online version: http://atlasgeneticsoncology.org/gene/50065/hla-dpb1