Identity
HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
DPB1,HLA-DP,HLA-DP1B,HLA-DPB
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3115
MIM: 142858
HGNC: 4940
Ensembl: ENSG00000223865
Variants:
dbSNP: 3115
ClinVar: 3115
TCGA: ENSG00000223865
COSMIC: HLA-DPB1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000223865 | ENST00000416804 | H0Y5P2 |
| ENSG00000223865 | ENST00000418931 | P04440 |
| ENSG00000223865 | ENST00000418931 | I4EC15 |
| ENSG00000223865 | ENST00000428835 | H0Y7G7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131285571 | aspirin-induced asthma | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 15007363, 9179433 | |
| PA443297 | Agranulocytosis | Disease | VariantAnnotation | associated | PD | 11266078 | |
| PA443450 | Asthma | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 15007363, 19392989, 9179433 | |
| PA445999 | Urticaria | Disease | VariantAnnotation | associated | PD | 15784113 | |
| PA447216 | Schizophrenia | Disease | VariantAnnotation | associated | PD | 11266078 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 15007363, 15784113, 19392989, 9179433 | |
| PA449061 | clozapine | Chemical | VariantAnnotation | associated | PD | 11266078 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37980631 | 2024 | The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility. | 0 |
| 38040271 | 2024 | HLA sequencing identifies novel associations and suggests clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis with polyangiitis. | 0 |
| 37980631 | 2024 | The effect of HLA-DP gene polymorphisms in Plasmodium Vivax-induced malaria susceptibility. | 0 |
| 38040271 | 2024 | HLA sequencing identifies novel associations and suggests clinical relevance of DPB1*04:01 in ANCA-associated Granulomatosis with polyangiitis. | 0 |
| 36074540 | 2023 | The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first identified in Korean individuals by next-generation sequencing. | 0 |
| 36394166 | 2023 | Characterization of the novel HLA-DPB1*1348:01 allele by sequencing-based typing. | 1 |
| 36411507 | 2023 | Characterization of the novel HLA-DPB1*11:01:06 allele by sequencing-based typing. | 1 |
| 36074540 | 2023 | The novel HLA-DPB1 allele, HLA-DPB1*1344:01, first identified in Korean individuals by next-generation sequencing. | 0 |
| 36394166 | 2023 | Characterization of the novel HLA-DPB1*1348:01 allele by sequencing-based typing. | 1 |
| 36411507 | 2023 | Characterization of the novel HLA-DPB1*11:01:06 allele by sequencing-based typing. | 1 |
| 33929277 | 2022 | Influence of HLA Class II Alleles and DRB1-DQB1 Haplotypes on Rheumatoid Arthritis Susceptibility and Autoantibody Status in the Chinese Han Population. | 2 |
| 35078690 | 2022 | Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population. | 0 |
| 35831411 | 2022 | Integrated transcriptomic and regulatory network analyses uncovers the role of let-7b-5p, SPIB, and HLA-DPB1 in sepsis. | 3 |
| 33929277 | 2022 | Influence of HLA Class II Alleles and DRB1-DQB1 Haplotypes on Rheumatoid Arthritis Susceptibility and Autoantibody Status in the Chinese Han Population. | 2 |
| 35078690 | 2022 | Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the axillary microbiome in a Japanese population. | 0 |
Citation
Dessen P
HLA-DPB1 (major histocompatibility complex, class II, DP beta 1)
Atlas Genet Cytogenet Oncol Haematol. 2008-03-01
Online version: http://atlasgeneticsoncology.org/gene/50065/hla-dpb1
