Identity
HGNC
LOCATION
6p21.32
LOCUSID
ALIAS
CELIAC1,DQ-A1,DQA1,HLA-DQA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3117
MIM: 146880
HGNC: 4942
Ensembl: ENSG00000196735
Variants:
dbSNP: 3117
ClinVar: 3117
TCGA: ENSG00000196735
COSMIC: HLA-DQA1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA131285571 | aspirin-induced asthma | Disease | VariantAnnotation | not associated | PD | 26366802 | |
| PA152241907 | lapatinib | Chemical | ClinicalAnnotation, LabelAnnotation, VariantAnnotation | associated | PD | 21245432, 24687830 | |
| PA164712708 | Drugs For Treatment Of Tuberculosis | Chemical | VariantAnnotation | associated | PD | 12359646 | |
| PA164769031 | lumiracoxib | Chemical | VariantAnnotation | associated | PD | 20639878 | |
| PA164925725 | Toxic liver disease | Disease | ClinicalAnnotation, VariantAnnotation | ambiguous | PD | 12359646, 20639878, 21245432, 24687830 | |
| PA165951292 | HLA-DQA1*02:01 | Haplotype | LabelAnnotation | associated | |||
| PA165951644 | HLA-DRB1*07:01:01:01 | Haplotype | LabelAnnotation | associated | |||
| PA443560 | Breast Neoplasms | Disease | VariantAnnotation | ambiguous | PD | 21245432, 24687830 | |
| PA443937 | Drug Toxicity | Disease | ClinicalAnnotation | associated | PD | 25217962 | |
| PA445220 | Pancreatitis | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 25217962 | |
| PA445941 | Tuberculosis | Disease | VariantAnnotation | ambiguous | PD | 12359646 | |
| PA446116 | Inflammatory Bowel Diseases | Disease | ClinicalAnnotation, VariantAnnotation | associated | PD | 25217962 | |
| PA448497 | aspirin | Chemical | VariantAnnotation | not associated | PD | 26366802 | |
| PA448515 | azathioprine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 25217962 | |
| PA450037 | interferon beta-1a | Chemical | ClinicalAnnotation | associated | PD | 21502966 | |
| PA450039 | interferon beta-1b | Chemical | ClinicalAnnotation | associated | PD | 21502966 | |
| PA450112 | isoniazid | Chemical | VariantAnnotation | not associated | PD | ||
| PA450196 | letrozole | Chemical | VariantAnnotation | not associated | PD | 21245432 | |
| PA450379 | mercaptopurine | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 25217962 | |
| PA451182 | pyrazinamide | Chemical | VariantAnnotation | not associated | PD | ||
| PA451250 | rifampin | Chemical | VariantAnnotation | not associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38182727 | 2024 | Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma. | 1 |
| 38182727 | 2024 | Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma. | 1 |
| 36394229 | 2023 | Identification of the novel HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 alleles in individuals from India. | 0 |
| 36403237 | 2023 | Characterization of the novel HLA-DQA1*02:01:14 allele by sequencing-based typing. | 1 |
| 36416663 | 2023 | Characterization of the novel HLA-DQA1*05:05:14 allele by sequencing-based typing. | 1 |
| 36468571 | 2023 | DQA1*0102 DQB1*0602 haplotype distinguishes coeliac disease and its complications from gluten unrelated enteropathies. | 0 |
| 37120605 | 2023 | Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome. | 3 |
| 37382296 | 2023 | Association Study Identified HLA-DQA1 as a Novel Genetic Risk of Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension. | 1 |
| 37406588 | 2023 | Identification of mutation gene prognostic biomarker in multiple myeloma through gene panel exome sequencing and transcriptome analysis in Chinese population. | 1 |
| 37460671 | 2023 | HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients. | 0 |
| 37958966 | 2023 | Candidate Genes for IgA Nephropathy in Pediatric Patients: Exome-Wide Association Study. | 0 |
| 38012279 | 2023 | A web-based genome-wide association study reveals the susceptibility loci of common adverse events following COVID-19 vaccination in the Japanese population. | 1 |
| 36394229 | 2023 | Identification of the novel HLA-DQA1*01:01:01:11 and -DQA1*01:03:01:13 alleles in individuals from India. | 0 |
| 36403237 | 2023 | Characterization of the novel HLA-DQA1*02:01:14 allele by sequencing-based typing. | 1 |
| 36416663 | 2023 | Characterization of the novel HLA-DQA1*05:05:14 allele by sequencing-based typing. | 1 |
Citation
Dessen P
HLA-DQA1 (major histocompatibility complex, class II, DQ alpha 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/43951/hla-dqa1
