Atlas of Genetics and Cytogenetics in Oncology and Haematology


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HLA-DQA2 (major histocompatibility complex, class II, DQ alpha 2)

Identity

Alias_namesHLA-DXA
Other aliasDC-alpha
DX-ALPHA
HLA-DCA
HLADQA2
HGNC (Hugo) HLA-DQA2
LocusID (NCBI) 3118
Atlas_Id 64331
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32741386 and ends at 32746887 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DQA2 (6p21.32) / HLA-DQA1 (6p21.32)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DQA2   4943
Cards
Entrez_Gene (NCBI)HLA-DQA2  3118  major histocompatibility complex, class II, DQ alpha 2
AliasesDC-alpha; DX-ALPHA; HLA-DCA; HLA-DXA; 
HLADQA2
GeneCards (Weizmann)HLA-DQA2
Ensembl hg19 (Hinxton)ENSG00000237541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000237541 [Gene_View]  ENSG00000237541 [Sequence]  chr6:32741386-32746887 [Contig_View]  HLA-DQA2 [Vega]
ICGC DataPortalENSG00000237541
TCGA cBioPortalHLA-DQA2
AceView (NCBI)HLA-DQA2
Genatlas (Paris)HLA-DQA2
WikiGenes3118
SOURCE (Princeton)HLA-DQA2
Genetics Home Reference (NIH)HLA-DQA2
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DQA2  -     chr6:32741386-32746887 +  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DQA2  -     6p21.32   [Description]    (hg19-Feb_2009)
GoldenPathHLA-DQA2 - 6p21.32 [CytoView hg19]  HLA-DQA2 - 6p21.32 [CytoView hg38]
ImmunoBaseENSG00000237541
Mapping of homologs : NCBIHLA-DQA2 [Mapview hg19]  HLA-DQA2 [Mapview hg38]
OMIM613503   
Gene and transcription
Genbank (Entrez)M95727 M95728
RefSeq transcript (Entrez)NM_020056
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DQA2
Cluster EST : UnigeneHs.591798 [ NCBI ]
CGAP (NCI)Hs.591798
Alternative Splicing GalleryENSG00000237541
Gene ExpressionHLA-DQA2 [ NCBI-GEO ]   HLA-DQA2 [ EBI - ARRAY_EXPRESS ]   HLA-DQA2 [ SEEK ]   HLA-DQA2 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DQA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3118
GTEX Portal (Tissue expression)HLA-DQA2
Human Protein AtlasENSG00000237541-HLA-DQA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP01906   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP01906  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP01906
Splice isoforms : SwissVarP01906
PhosPhoSitePlusP01906
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_a_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_alpha (PF00993)   
Domain families : Pfam (NCBI)pfam07654    pfam00993   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_alpha (SM00920)  
Conserved Domain (NCBI)HLA-DQA2
DMDM Disease mutations3118
Blocks (Seattle)HLA-DQA2
SuperfamilyP01906
Human Protein Atlas [tissue]ENSG00000237541-HLA-DQA2 [tissue]
Peptide AtlasP01906
HPRD09982
IPIIPI00005172   IPI01021280   IPI00892765   
Protein Interaction databases
DIP (DOE-UCLA)P01906
IntAct (EBI)P01906
FunCoupENSG00000237541
BioGRIDHLA-DQA2
STRING (EMBL)HLA-DQA2
ZODIACHLA-DQA2
Ontologies - Pathways
QuickGOP01906
Ontology : AmiGOGolgi membrane  adaptive immune response  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  adaptive immune response  lysosomal membrane  plasma membrane  integral component of plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
NDEx NetworkHLA-DQA2
Atlas of Cancer Signalling NetworkHLA-DQA2
Wikipedia pathwaysHLA-DQA2
Orthology - Evolution
OrthoDB3118
GeneTree (enSembl)ENSG00000237541
Phylogenetic Trees/Animal Genes : TreeFamHLA-DQA2
HOGENOMP01906
Homologs : HomoloGeneHLA-DQA2
Homology/Alignments : Family Browser (UCSC)HLA-DQA2
Gene fusions - Rearrangements
Fusion : QuiverHLA-DQA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DQA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DQA2
dbVarHLA-DQA2
ClinVarHLA-DQA2
1000_GenomesHLA-DQA2 
Exome Variant ServerHLA-DQA2
ExAC (Exome Aggregation Consortium)ENSG00000237541
GNOMAD BrowserENSG00000237541
Varsome BrowserHLA-DQA2
Genetic variants : HAPMAP3118
Genomic Variants (DGV)HLA-DQA2 [DGVbeta]
DECIPHERHLA-DQA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DQA2 
Mutations
ICGC Data PortalHLA-DQA2 
TCGA Data PortalHLA-DQA2 
Broad Tumor PortalHLA-DQA2
OASIS PortalHLA-DQA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DQA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHLA-DQA2
Mutations and Diseases : HGMDHLA-DQA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DQA2
DgiDB (Drug Gene Interaction Database)HLA-DQA2
DoCM (Curated mutations)HLA-DQA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DQA2 (select a term)
intoGenHLA-DQA2
Cancer3DHLA-DQA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613503   
Orphanet
DisGeNETHLA-DQA2
MedgenHLA-DQA2
Genetic Testing Registry HLA-DQA2
NextProtP01906 [Medical]
TSGene3118
GENETestsHLA-DQA2
Target ValidationHLA-DQA2
Huge Navigator HLA-DQA2 [HugePedia]
snp3D : Map Gene to Disease3118
BioCentury BCIQHLA-DQA2
ClinGenHLA-DQA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3118
Chemical/Pharm GKB GenePA35067
Clinical trialHLA-DQA2
Miscellaneous
canSAR (ICR)HLA-DQA2 (select the gene name)
DataMed IndexHLA-DQA2
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DQA2
EVEXHLA-DQA2
GoPubMedHLA-DQA2
iHOPHLA-DQA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:31:12 CEST 2019

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