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HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2)

Identity

Alias_namesHLA-DXB
Other aliasDQB2
HLA-DQB1
HGNC (Hugo) HLA-DQB2
LocusID (NCBI) 3120
Atlas_Id 64332
Location 6p21.32  [Link to chromosome band 6p21]
Location_base_pair Starts at 32756098 and ends at 32763553 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HLA-DQB2 (6p21.32) / NDUFS1 (2q33.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)HLA-DQB2   4945
Cards
Entrez_Gene (NCBI)HLA-DQB2  3120  major histocompatibility complex, class II, DQ beta 2
AliasesDQB2; HLA-DQB1; HLA-DXB
GeneCards (Weizmann)HLA-DQB2
Ensembl hg19 (Hinxton)ENSG00000232629 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000232629 [Gene_View]  ENSG00000232629 [Sequence]  chr6:32756098-32763553 [Contig_View]  HLA-DQB2 [Vega]
ICGC DataPortalENSG00000232629
TCGA cBioPortalHLA-DQB2
AceView (NCBI)HLA-DQB2
Genatlas (Paris)HLA-DQB2
WikiGenes3120
SOURCE (Princeton)HLA-DQB2
Genetics Home Reference (NIH)HLA-DQB2
Genomic and cartography
GoldenPath hg38 (UCSC)HLA-DQB2  -     chr6:32756098-32763553 -  6p21.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)HLA-DQB2  -     6p21.32   [Description]    (hg19-Feb_2009)
GoldenPathHLA-DQB2 - 6p21.32 [CytoView hg19]  HLA-DQB2 - 6p21.32 [CytoView hg38]
ImmunoBaseENSG00000232629
Mapping of homologs : NCBIHLA-DQB2 [Mapview hg19]  HLA-DQB2 [Mapview hg38]
OMIM615161   
Gene and transcription
Genbank (Entrez)AK098007 BC031995 M95729
RefSeq transcript (Entrez)NM_001198858 NM_001300790 NM_182549
RefSeq genomic (Entrez)NC_000006 NT_113891 NT_167244 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)HLA-DQB2
Cluster EST : UnigeneHs.731563 [ NCBI ]
CGAP (NCI)Hs.731563
Alternative Splicing GalleryENSG00000232629
Gene ExpressionHLA-DQB2 [ NCBI-GEO ]   HLA-DQB2 [ EBI - ARRAY_EXPRESS ]   HLA-DQB2 [ SEEK ]   HLA-DQB2 [ MEM ]
Gene Expression Viewer (FireBrowse)HLA-DQB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3120
GTEX Portal (Tissue expression)HLA-DQB2
Human Protein AtlasENSG00000232629-HLA-DQB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05538   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05538  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05538
Splice isoforms : SwissVarP05538
PhosPhoSitePlusP05538
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    IG_MHC (PS00290)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig/MHC_CS    Ig_C1-set    MHC_I/II-like_Ag-recog    MHC_II_a/b_N    MHC_II_b_N   
Domain families : Pfam (Sanger)C1-set (PF07654)    MHC_II_beta (PF00969)   
Domain families : Pfam (NCBI)pfam07654    pfam00969   
Domain families : Smart (EMBL)IGc1 (SM00407)  MHC_II_beta (SM00921)  
Domain structure : Prodom (Prabi Lyon)MHC_II_b_N (PD000328)   
Conserved Domain (NCBI)HLA-DQB2
DMDM Disease mutations3120
Blocks (Seattle)HLA-DQB2
SuperfamilyP05538
Human Protein Atlas [tissue]ENSG00000232629-HLA-DQB2 [tissue]
Peptide AtlasP05538
HPRD09983
IPIIPI00829714   IPI00218637   IPI00641356   IPI00647079   IPI00938268   IPI00914886   IPI00848108   IPI00395557   
Protein Interaction databases
DIP (DOE-UCLA)P05538
IntAct (EBI)P05538
FunCoupENSG00000232629
BioGRIDHLA-DQB2
STRING (EMBL)HLA-DQB2
ZODIACHLA-DQB2
Ontologies - Pathways
QuickGOP05538
Ontology : AmiGOGolgi membrane  adaptive immune response  lysosomal membrane  plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Ontology : EGO-EBIGolgi membrane  adaptive immune response  lysosomal membrane  plasma membrane  immune response  endosome membrane  ER to Golgi transport vesicle membrane  antigen processing and presentation of exogenous peptide antigen via MHC class II  transport vesicle membrane  endocytic vesicle membrane  clathrin-coated endocytic vesicle membrane  MHC class II receptor activity  trans-Golgi network membrane  MHC class II protein complex  T cell receptor signaling pathway  interferon-gamma-mediated signaling pathway  integral component of lumenal side of endoplasmic reticulum membrane  
Pathways : KEGGType I diabetes mellitus    Antigen processing and presentation    Cell adhesion molecules (CAMs)   
NDEx NetworkHLA-DQB2
Atlas of Cancer Signalling NetworkHLA-DQB2
Wikipedia pathwaysHLA-DQB2
Orthology - Evolution
OrthoDB3120
GeneTree (enSembl)ENSG00000232629
Phylogenetic Trees/Animal Genes : TreeFamHLA-DQB2
HOGENOMP05538
Homologs : HomoloGeneHLA-DQB2
Homology/Alignments : Family Browser (UCSC)HLA-DQB2
Gene fusions - Rearrangements
Fusion : QuiverHLA-DQB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerHLA-DQB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)HLA-DQB2
dbVarHLA-DQB2
ClinVarHLA-DQB2
1000_GenomesHLA-DQB2 
Exome Variant ServerHLA-DQB2
ExAC (Exome Aggregation Consortium)ENSG00000232629
GNOMAD BrowserENSG00000232629
Varsome BrowserHLA-DQB2
Genetic variants : HAPMAP3120
Genomic Variants (DGV)HLA-DQB2 [DGVbeta]
DECIPHERHLA-DQB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisHLA-DQB2 
Mutations
ICGC Data PortalHLA-DQB2 
TCGA Data PortalHLA-DQB2 
Broad Tumor PortalHLA-DQB2
OASIS PortalHLA-DQB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICHLA-DQB2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DHLA-DQB2
Mutations and Diseases : HGMDHLA-DQB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch HLA-DQB2
DgiDB (Drug Gene Interaction Database)HLA-DQB2
DoCM (Curated mutations)HLA-DQB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)HLA-DQB2 (select a term)
intoGenHLA-DQB2
Cancer3DHLA-DQB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615161   
Orphanet
DisGeNETHLA-DQB2
MedgenHLA-DQB2
Genetic Testing Registry HLA-DQB2
NextProtP05538 [Medical]
TSGene3120
GENETestsHLA-DQB2
Target ValidationHLA-DQB2
Huge Navigator HLA-DQB2 [HugePedia]
snp3D : Map Gene to Disease3120
BioCentury BCIQHLA-DQB2
ClinGenHLA-DQB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3120
Chemical/Pharm GKB GenePA35069
Clinical trialHLA-DQB2
Miscellaneous
canSAR (ICR)HLA-DQB2 (select the gene name)
DataMed IndexHLA-DQB2
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineHLA-DQB2
EVEXHLA-DQB2
GoPubMedHLA-DQB2
iHOPHLA-DQB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 15:31:13 CEST 2019

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