HMBOX1 (homeobox containing 1)

2010-03-01  

Identity

HGNC
HMBOX1
LOCATION
8p21.1
LOCUSID
79618
ALIAS
HNF1LA,HOT1,PBHNF,TAH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79618
MIM: 618610
HGNC: 26137
Ensembl: ENSG00000147421

Variants:

dbSNP: 79618
ClinVar: 79618
TCGA: ENSG00000147421
COSMIC: HMBOX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147421ENST00000287701Q6NT76
ENSG00000147421ENST00000355231E5RGZ2
ENSG00000147421ENST00000397358Q6NT76
ENSG00000147421ENST00000519047E5RGZ2
ENSG00000147421ENST00000519662E5RHH9
ENSG00000147421ENST00000521516Q6NT76
ENSG00000147421ENST00000522468H0YBM8
ENSG00000147421ENST00000523613H0YKJ1
ENSG00000147421ENST00000524238Q6NT76
ENSG00000147421ENST00000558662Q6NT76
ENSG00000147421ENST00000560599H0YLF2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
236853562013HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.26
223202172012miR-30c-1* promotes natural killer cell cytotoxicity against human hepatoma cells by targeting the transcription factor HMBOX1.18
168257642006Isolation and functional analysis of human HMBOX1, a homeobox containing protein with transcriptional repressor activity.15
264562202015HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.13
217060442011HMBOX1 negatively regulates NK cell functions by suppressing the NKG2D/DAP10 signaling pathway.11
238139582013The telomere-associated homeobox-containing protein TAH1/HMBOX1 participates in telomere maintenance in ALT cells.9
201824372010High-mobility group box-1 protein in tracheal aspirates from premature infants: relationship with bronchopulmonary dysplasia and steroid therapy.8
197289272009Recombinant expression of a novel human transcriptional repressor HMBOX1 and preparation of anti-HMBOX1 monoclonal antibody.4
218398582011HMBOX1, homeobox transcription factor, negatively regulates interferon-γ production in natural killer cells.4

Citation

Dessen P

HMBOX1 (homeobox containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51358/hmbox1