HMCES (5-hydroxymethylcytosine binding, ES cell specific)

2014-11-01  

Identity

HGNC
LOCATION
3q21.3
LOCUSID
ALIAS
C3orf37,DC12,SRAPD1
FUSION GENES

Other Information

Locus ID:

NCBI: 56941
MIM: 618288
HGNC: 24446
Ensembl: ENSG00000183624

Variants:

dbSNP: 56941
ClinVar: 56941
TCGA: ENSG00000183624
COSMIC: HMCES

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183624ENST00000383463Q96FZ2
ENSG00000183624ENST00000389735Q96FZ2
ENSG00000183624ENST00000417226E7EMP6
ENSG00000183624ENST00000502878Q96FZ2
ENSG00000183624ENST00000509042D6R9T3
ENSG00000183624ENST00000509551D6RAZ3
ENSG00000183624ENST00000510314D6RGK7
ENSG00000183624ENST00000511665D6RAI0

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243879842014Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.89
246796042014Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain.34
263567092015Epigenetic Modifications in the Biology of Nonalcoholic Fatty Liver Disease: The Role of DNA Hydroxymethylation and TET Proteins.18
258273052015Prognostic values of 5-hmC, 5-mC and TET2 in epithelial ovarian cancer.10
312359132019Structural basis of HMCES interactions with abasic DNA and multivalent substrate recognition.8
2547135120155-Hydroxymethylcytosine, the "Sixth Base", during brain development and ageing.6

Citation

Dessen P

HMCES (5-hydroxymethylcytosine binding, ES cell specific)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64342/hmces