HMGB3 (high mobility group box 3)

2007-04-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
HMG-2a,HMG-4,HMG2A,HMG4
FUSION GENES

Other Information

Locus ID:

NCBI: 3149
MIM: 300193
HGNC: 5004
Ensembl: ENSG00000029993

Variants:

dbSNP: 3149
ClinVar: 3149
TCGA: ENSG00000029993
COSMIC: HMGB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000029993ENST00000325307O15347
ENSG00000029993ENST00000419110E7ES08
ENSG00000029993ENST00000430118E9PES6
ENSG00000029993ENST00000448905O15347
ENSG00000029993ENST00000455596E7EQU1

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
240984902013Tumor suppressive function of mir-205 in breast cancer is linked to HMGB3 regulation.38
229128792012Hmgb3 is regulated by microRNA-206 during muscle regeneration.19
257557212015Increased expression of HMGB3: a novel independent prognostic marker of worse outcome in patients with esophageal squamous cell carcinoma.18
286788252017HMGB3 promotes growth and migration in colorectal cancer by regulating WNT/β-catenin pathway.16
236090342013Prognostic value of HMGB3 expression in patients with non-small cell lung cancer.15
256472622015Overexpression of HMGB3 protein promotes cell proliferation, migration and is associated with poor prognosis in urinary bladder cancer patients.15
291967332018Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis.14
273633342016MiR-27b is epigenetically downregulated in tamoxifen resistant breast cancer cells due to promoter methylation and regulates tamoxifen sensitivity by targeting HMGB3.13
250959792014Upregulation of miR-513b inhibits cell proliferation, migration, and promotes apoptosis by targeting high mobility group-box 3 protein in gastric cancer.10
233261402012High mobility group-box 3 overexpression is associated with poor prognosis of resected gastric adenocarcinoma.9

Citation

Dessen P

HMGB3 (high mobility group box 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47167/hmgb3