Identity
HGNC
LOCATION
2q22.1
LOCUSID
ALIAS
HMT,HNMT-S1,HNMT-S2,MRT51
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3176
MIM: 605238
HGNC: 5028
Ensembl: ENSG00000150540
Variants:
dbSNP: 3176
ClinVar: 3176
TCGA: ENSG00000150540
COSMIC: HNMT
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA130620651 | anthracyclines and related substances | Chemical | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 21900104, 23441093 | |
| PA448497 | aspirin | Chemical | ClinicalAnnotation | associated | PD | 19178400 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35163585 | 2022 | HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer. | 10 |
| 36378841 | 2022 | The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis. | 0 |
| 35163585 | 2022 | HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer. | 10 |
| 36378841 | 2022 | The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis. | 0 |
| 34680041 | 2021 | Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease. | 4 |
| 34680041 | 2021 | Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease. | 4 |
| 29506638 | 2018 | MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase. | 11 |
| 29564728 | 2018 | Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations. | 9 |
| 29506638 | 2018 | MicroRNA-223 is involved in the pathogenesis of atopic dermatitis by affecting histamine-N-methyltransferase. | 11 |
| 29564728 | 2018 | Determining the Effect of the HNMT, STK39, and NMD3 Polymorphisms on the Incidence of Parkinson's Disease, Amyotrophic Lateral Sclerosis, and Multiple System Atrophy in Chinese Populations. | 9 |
| 27130307 | 2017 | Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies. | 9 |
| 27769936 | 2017 | Leucine 208 in human histamine N-methyltransferase emerges as a hotspot for protein stability rationalizing the role of the L208P variant in intellectual disability. | 3 |
| 27837280 | 2017 | Thr105Ile (rs11558538) polymorphism in the histamine-1-methyl-transferase (HNMT) gene and risk for restless legs syndrome. | 4 |
| 28400155 | 2017 | Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients. | 4 |
| 27130307 | 2017 | Association of diamine oxidase and histamine N-methyltransferase polymorphisms with presence of migraine in a group of Mexican mothers of children with allergies. | 9 |
Citation
Dessen P
HNMT (histamine N-methyltransferase)
Atlas Genet Cytogenet Oncol Haematol. 2011-03-01
Online version: http://atlasgeneticsoncology.org/gene/52107/hnmt
