HNMT (histamine N-methyltransferase)

2011-03-01  

Identity

HGNC
HNMT
LOCATION
2q22.1
LOCUSID
3176
ALIAS
HMT,HNMT-S1,HNMT-S2,MRT51
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3176
MIM: 605238
HGNC: 5028
Ensembl: ENSG00000150540

Variants:

dbSNP: 3176
ClinVar: 3176
TCGA: ENSG00000150540
COSMIC: HNMT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150540ENST00000280096P50135
ENSG00000150540ENST00000280097P50135
ENSG00000150540ENST00000329366P50135
ENSG00000150540ENST00000410115P50135
ENSG00000150540ENST00000475675P50135

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Histidine metabolismKEGGko00340
Histidine metabolismKEGGhsa00340
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Histidine catabolismREACTOMER-HSA-70921
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656
Selenoamino acid metabolismREACTOMER-HSA-2408522
Metabolism of ingested SeMet, Sec, MeSec into H2SeREACTOMER-HSA-2408508

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130620651anthracyclines and related substancesChemicalClinicalAnnotationassociatedPD21900104, 23441093
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPD21900104, 23441093
PA448497aspirinChemicalClinicalAnnotationassociatedPD19178400

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
198984822009Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.84
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
205511632010The role of histamine degradation gene polymorphisms in moderating the effects of food additives on children's ADHD symptoms.19
205032872010Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.17
157701032005Thr105Ile, a functional polymorphism of histamine N-methyltransferase, is associated with alcoholism in two independent populations.14

Citation

Dessen P

HNMT (histamine N-methyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52107/hnmt