HNRNPDL (heterogeneous nuclear ribonucleoprotein D like)

2016-10-01  

Identity

HGNC
LOCATION
4q21.22
LOCUSID
ALIAS
HNRNP,HNRPDL,JKTBP,JKTBP2,LGMD1G,LGMDD3,laAUF1
FUSION GENES

Other Information

Locus ID:

NCBI: 9987
MIM: 607137
HGNC: 5037
Ensembl: ENSG00000152795

Variants:

dbSNP: 9987
ClinVar: 9987
TCGA: ENSG00000152795
COSMIC: HNRNPDL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152795ENST00000295470O14979
ENSG00000152795ENST00000295470A0A024RDF6
ENSG00000152795ENST00000349655O14979
ENSG00000152795ENST00000502762O14979
ENSG00000152795ENST00000502762A0A024RDF6
ENSG00000152795ENST00000507721O14979
ENSG00000152795ENST00000514511A0A087WU03
ENSG00000152795ENST00000602300O14979
ENSG00000152795ENST00000614627A0A087WUK2
ENSG00000152795ENST00000621267O14979
ENSG00000152795ENST00000621267A0A024RDF6
ENSG00000152795ENST00000630114O14979
ENSG00000152795ENST00000630827O14979

Expression (GTEx)

0
50
100
150
200
250
300
350

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246476042014A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G).32
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
180951542008Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers.9
213000692011JKTBP1 is involved in stabilization and IRES-dependent translation of NRF mRNAs by binding to 5' and 3' untranslated regions.7
292631342018Auto- and cross-regulation of the hnRNPs D and DL.7
175920412007NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element.6
304473472019hnRNPDL extensively regulates transcription and alternative splicing.5
183816622008Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R).3
300527122018Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle.2
236422682013Proteomic analyses and identification of arginine methylated proteins differentially recognized by autosera from anti-Sm positive SLE patients.1

Citation

Dessen P

HNRNPDL (heterogeneous nuclear ribonucleoprotein D like)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56404/hnrnpdl