HOMER1 (homer scaffold protein 1)

2015-02-01  

Identity

HGNC
LOCATION
5q14.1
LOCUSID
ALIAS
HOMER,HOMER1A,HOMER1B,HOMER1C,SYN47,Ves-1
FUSION GENES

Other Information

Locus ID:

NCBI: 9456
MIM: 604798
HGNC: 17512
Ensembl: ENSG00000152413

Variants:

dbSNP: 9456
ClinVar: 9456
TCGA: ENSG00000152413
COSMIC: HOMER1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152413ENST00000282260Q86YM7
ENSG00000152413ENST00000334082Q86YM7
ENSG00000152413ENST00000508576Q86YM7
ENSG00000152413ENST00000535690Q86YM6

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
FoxO signaling pathwayKEGGhsa04068
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445254Parkinson DiseaseDiseaseClinicalAnnotationassociatedPD24126708
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437
PA450213levodopaChemicalClinicalAnnotationassociatedPD24126708

References

Pubmed IDYearTitleCitations
211726142010Homeostatic scaling requires group I mGluR activation mediated by Homer1a.100
206738762010Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.72
206738762010Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.72
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
225581072012High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism.47
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
230447062013Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels.20
227498572012Scaffold protein Homer 1: implications for neurological diseases.17
205987112011Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients.16

Citation

Dessen P

HOMER1 (homer scaffold protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55049/homer1