HOPX (HOP homeobox)

2003-06-01  

Identity

HGNC
HOPX
LOCATION
4q12
LOCUSID
84525
ALIAS
CAMEO,HOD,HOP,LAGY,NECC1,OB1,SMAP31,TOTO
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84525
MIM: 607275
HGNC: 24961
Ensembl: ENSG00000171476

Variants:

dbSNP: 84525
ClinVar: 84525
TCGA: ENSG00000171476
COSMIC: HOPX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171476ENST00000317745Q9BPY8
ENSG00000171476ENST00000337881Q9BPY8
ENSG00000171476ENST00000381255Q9BPY8
ENSG00000171476ENST00000381260Q9BPY8
ENSG00000171476ENST00000420433Q9BPY8
ENSG00000171476ENST00000503639Q9BPY8
ENSG00000171476ENST00000508121Q9BPY8
ENSG00000171476ENST00000553379Q9BPY8
ENSG00000171476ENST00000554144Q9BPY8
ENSG00000171476ENST00000555760Q9BPY8
ENSG00000171476ENST00000556376Q9BPY8
ENSG00000171476ENST00000556614Q9BPY8

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217002222011Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex.56
237077822013Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.55
202288412010Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer.32
229046742012Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer.29
302901792018Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation.27
281461492017HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma.22
182349602008HOP/OB1/NECC1 promoter DNA is frequently hypermethylated and involved in tumorigenic ability in esophageal squamous cell carcinoma.18
210614322010Persistence of effector memory Th1 cells is regulated by Hopx.18
191732922009Homeobox gene HOPX is epigenetically silenced in human uterine endometrial cancer and suppresses estrogen-stimulated proliferation of cancer cells by inhibiting serum response factor.17
169392102006Analysis of the structure and function of the transcriptional coregulator HOP.16

Citation

Dessen P

HOPX (HOP homeobox)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40845/hopx